+Donnelly, E; Meredith, DS; Gladnick, BP; Rebolledo BJ; Lane JM; Boskey, AL +Hospital for Special Surgery, New York, NY [email protected] INTRODUCTION Bisphosphonate therapy reduces fracture incidence in osteoporotic patients, and the safety and efficacy of alendronate is generally preserved with treatment durations as long as 10 years [1]. Although no significant association between bisphosphona...

Introduction: Treatment of edentulous atrophic mandible with severe atrophy is a challenge based on local conditions and systemic diseases confronted by the age group affected. If bone grafting is indicated, it is often used in lateral or inferior aspects of the mandible.  Case Report: A 70-year-old male with a unilateral fracture of the atrophied left mandibular body was managed by lingual bon...

Bone properties and response behavior after static or dynamic activation (loading) are still interesting topics in many fields of the science especially in the biomechanical problems such as bone loss of astronauts in space, osteoporosis, bone remodeling after fracture or remodeling after surgery (endoprosthesis and implants) and in osteointegration. This contribution deals with the relation be...

Giant cell tumor (GCT) is a primary and benign tumor of bone, albeit locally aggressive in some cases, such as in the epi-metaphyseal region of long bones, predominantly the distal end of femur and proximal end of tibia (1). There are a variety of treatments for a bone affected by GCT, ranging from chemotherapy, radiotherapy, embolization, and cryosurgery, to surgery with the use of chemical or...

Long-term alcohol consumption can interfere with bone growth and replacement of bone tissue (i.e., remodeling), resulting in decreased bone density and increased risk of fracture. These effects may be exerted directly or indirectly through the many cell types, hormones, and growth factors that regulate bone metabolism. Alcohol consumption during adolescence reduces peak bone mass and can result...

PURPOSE The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and health in physically active individuals. METHODS We reviewed the literature on the short-term effects of low EA on markers of bone metabolism and the long-term effects of low EA on outcomes relating to bone health (bone mass, microarchi...

Long term bisphosphonate use has been associated with "atypical" subtrochanteric and diaphyseal fractures of the femoral shaft. We are reporting a case of pelvic fractures in addition to atypical long bone fractures, in a patient with osteopenia treated with bisphosphonate for 8 years, and teriparatide for 2 years. After 5 years of bisphosphonate therapy the patient suffered an atraumatic fract...

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass....