This paper reports a RP-HPLC method for the determination of Lomustine (CCNU) in mouse tumor tissue. CCNU was separated and determined on a reverse-phase C18 5 microm column with a mobile phase of H2O-acetonitrile (54:46), detected at 254 nm and no internal standard. The calibration curve was linear (r = 0.9999) within the range of 0.98-15.68 microg/ml for CCNU. The recovery ratio of CCNU was 6...

PROBLEM: Many health care organizations have focused on improving safety with parenteral chemotherapy but have done less to ensure safe practices with oral chemotherapy. Although oral chemotherapy is associated with ease of administration, an error with an oral agent can be just as deadly as an error with a parenteral formulation. Two years ago Ruth Ann Collins, a 60-year-old woman with a histo...

Glioblastoma multiforme is a highly aggressive primary cancer of the brain associated with a poor prognosis. Modest increases in survival can sometimes be achieved with the use of temozolomide and radiation therapy after surgery, but second-line therapy after recurrence has a limited efficacy. Curcumin has demonstrated promising results against this form of cancer in experimental models. The re...

BACKGROUND Based on a promising pilot study with weekly carboplatin and teniposide (CBDCA/VM) the Swiss Group for Clinical Cancer Research (SAKK) performed a randomised phase III trial in patients with extensive-disease small-cell lung cancer aimed at the development of an effective palliative treatment with low subjective toxicity. PATIENTS AND METHODS From September 1989 to September 1991 p...

Acute myeloblastic leukemia (AML), although liable to occur at any age (including children) is however mostly a disease of the elderly. The ongoing progression of human life-span makes it likely that this pathology will be of growing importance in the coming years. It is therefore a clear public health issue to find ways of efficiently treating these patients while preserving as much as possibl...

Several anticancer drugs have been added to the therapeutic armamentarium in recent years. Some of these agents are traditional drugs with a long history of use in human oncology. Increased sophistication in clinical trial design in veterinary oncology has allowed the incorporation of agents previously viewed as excessively toxic. Other agents have been developed more recently. This article sum...