After many years of studies on the renin–angiotensin system (RAS), one of the central concepts is that the RAS forms an effective defence mechanism against low-sodium states and hypotension. Low-perfusion pressure sensed by the afferent arteriole, low-distal delivery sensed by the macula densa and low blood pressure sensed by the sympathetic nervous system increase renin release, leading to ang...

This study aimed to investigate the realizations of verbs’ syntactic and semantic features inmoves of applied linguistics research article introductions published in international andIranian local journals. To this end, a data of 30 research article introductions (15 published inIranian local journals and 15 in high impact international journals) was selected. The researcharticle introductions ...

A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell li...

Background There is an increasing trend of international migration of health professionals from low- and middle- income countries to high-income countries as well as across middle-income countries. The WHO Global Code of Practice on the International Recruitment of Health Personnel was created to better address health workforce development and the ethical conduct of international recruitment. T...

Background and Aim: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral mucosa. The etiopathogenesis of RAS is not clear. RAS is multifactorial, and several factors can contribute to RAS development. This study aimed to evaluate the RAS prevalence and some related factors in 12-17-year-old schoolchildren in Zahedan City (Southeast of Iran). Materials and Methods: ...

The renin-angiotensin system (RAS) is usually associated with its systemic action on cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level, the RAS influences tumour growth. The potential of the RAS as a target for cancer treatment and the suggested underlying mechanisms of its paracrine effects are reviewed here. These include modulation of angiogenesis, cel...

Beside the basic control system associated with the hypothalamus-hypophysis-thyroid axis and thyrotropin, a growing evidence suggests that thyroid function is influenced by a vast spectrum of locally produced factors. Renin-angiotensin system (RAS) is considered as one of the most powerful and effective regulatory systems in humans. In the “classical” cascade of RAS, angiotensinogen is enzymati...

The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular volume homeostasis and blood pressure through complex mechanisms. Apart from the well known systemic RAS, occurrence of a local RAS has been documented in multiple tissues, including the kidney. A large body of recent evidence from pharmacologic and genetic studies, particularly those using various transge...

fasting and diabetes has been on my radar from a local perspective for years. as a dietitian many of my patients chose to fast with the goal to promote better health. most recently, my perspective on fasting became global as working with the managing diabetes during ramadan initiatives.in april 2016, international diabetes federation (idf) and the diabetes and ramadan (dar) international allian...