this study aims to numerically investigate on the crashworthiness of thin-walled square tubes by consideration of 3-d oblique loading. in this type of loading, direction of loading is defined by using two spatial angles relative to the position of the tube. to this aim, finite element (fe) analysis is employed to simulate the loading for 8 different numerical models with different loading orien...

Nanoparticle (NP) drug loading is one of the key defining characteristics of an NP formulation. However, the effect of NP drug loading on therapeutic efficacy and pharmacokinetics has not been thoroughly evaluated. Herein, we characterized the efficacy, toxicity and pharmacokinetic properties of NP docetaxel formulations that have differential drug loading but are otherwise identical. Particle ...

Objective(s): Chitosan, a biodegradable and cationic polysaccharide with increasing applications in biomedicine, possesses many advantages including mucoadhesivity, biocompatibility, and low-immunogenicity. The aim of this study, was investigating the influence of pH, ratio of azelaic acid/chitosan and molecular weight of chitosan on loading efficiency of azelaic acid in chitosan particles. Mat...

Dairy wastewater is enriched in organic matter (about 45-72 g/l, COD) and also contains biodegradable carbohydrates. A three-stage system, NRBC was fabricated as a bench scale unit for lab experiments, to remove organic carbon from the whey. The fabricated NRBC had several advantages, such as quick start-up, high biomass concentration and was additionally able to handle high organic loading rat...

This project outlines procedures and resources used on the construction of polycyclic aromatic hydrocarbon (PAH) susceptibility model. The PAH susceptibility is due to PAH loading from impervious surface features in the watershed. The susceptibility model determines areas in the watershed which contribute to PAH loading. These hotspots represent areas that should be closely monitored, as they h...

the pseudo-elastic behavior of shape memory alloy (sma) truss and cantilever beam are investigated. brinson’s one-dimensional material model, which uses the twinned and detwinned martensite fractions separately as internal variables, is applied in the algorithm to establish the sma stress-strain characteristics. this material model also incorporates different young’s modulus for austenitic and ...

the present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. sba-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (mpts). the parent and thiol-functionalized sba-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). the charac...

The aim of the project was to create finite element model of a commercially available wrist implant to examine its behaviour under loading. The finite element model was validated by carrying out mechanical tests. Little is known about the mechanics of wrist implants under loading and how they interact with the surrounding bone. Surgical outcomes have been poor and further research is needed to ...

Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT.  In the first step, following the purification of semi-crude DT by the ion-exchan...