An assembly of two receptor ligand bonds in series will typically break at the weaker complex upon application of an external force. The rupture site depends highly on the binding potentials of both bonds and on the loading rate of the applied force. A model is presented that allows simulations of force-induced rupture of bonds in series at a given force and loading rate based on the natural di...

The stability of the polyethylene acetabulum cemented on a substrate made of frozen bone grafts was investigated. The force was applied to the edge of the acetabulum and the magnitude of the force and resulting displacement were recorded. These tests were preceded by stress testing, during which the acetabulum was subjected to loading forces of 1 or 3 kN through 100,000 cycles. Additionally the...

Electromyographic (EMG) amplitude and mechanical tension are directly related during isometric contraction. Maximal voluntary isometric contractions are typically elicited through two different procedures; resisting a load, which is eccentric in nature, and contracting against an immovable object, which is concentric in nature. A wealth of literature exists indicating that EMG amplitude during ...

Mechanical properties of neutrophils have been recognized as key contributors to stabilizing neutrophil rolling on the endothelium during the inflammatory response. In particular, accumulating evidence suggests that surface protrusion and tether extraction from neutrophils facilitate stable rolling by relieving the disruptive forces on adhesive bonds. Using a customized optical trap setup, we a...

UNLABELLED Mechanical strain applied to bone leads to bone remodeling. In the oral cavity, it is unclear how such mechanical force applied to move teeth orthodontically induces alveolar bone remodeling. It is known that osteoclasts are the only cells that are responsible for bone resorption, while the formation and activity of osteoclasts are regulated by osteoblasts. So it is believed that ost...

Taking the molding block thickness, relaxation ratio and shatter resistance as evaluation indicators, the effects of compression parameters, which include mold form, compressive force, pressure-holding time and loading rate, on molding block quality of fish floss were investigated by means of single factor and orthogonal test. The results show that: 1) the mold form, compressive force, pressure...

Early tendon healing can be stimulated by mechanical loading and inhibited by cyclooxygenase (COX) inhibitors (nonsteroidal anti-inflammatory drugs). Therefore, we investigated if impairment of tendon healing by a COX-2 inhibitor (parecoxib) is related to loading. Because loading might infer microdamage, which also stimulates healing, we also investigated if this effect is inhibited by parecoxi...

This paper introduces a technique that relates the coefficients of the Magic Formula tire model to the physical properties of the tire. For this purpose, the tire model is developed by ABAQUS commercial software. The output of this model for the lateral tire force is validated by available tire information and then used to identify the tire force properties. The Magic Formula coefficients are o...

Dynamic force spectroscopy was used to test force-induced dissociation of the complex between the integrin α7β1 and the bacterial protein invasin. Both proteins were used in truncated forms comprising the respective binding sites. Using the biomembrane force-probe, the bond system was exposed to 14 different loading rates ranging from 18 pN/s to 5.3 nN/s. At each rate, bond rupture spectra were...

Alterations in hip joint loading have been associated with diseases such as arthritis and osteoporosis. Understanding the relationship between gait speed and hip joint loading in healthy hips may illuminate changes in gait mechanics as walking speed deviates from preferred. The purpose of this study was to quantify hip joint loading during the gait cycle and identify differences with varying sp...