The effect of feeding 1% cuttlefish (Sepia pharaonis) liver oil for a period of 45 days on immune function, inflammatory response and platelet aggregation was studied in male albino Sprague Dawley rats. In liver oil-treated animals, spleen cell proliferation was significantly higher, especially in the presence of mitogen. The bone marrow cells also showed enhanced proliferation in the treated a...

Non-alcoholic fatty liver disease (NAFLD) is triggered by a nutritional-metabolic alteration characterized by triacylglicerides acumulation, insulin resistance (IR), oxidative stress and depletion of polyunsaturated fatty acid (PUFA). The n-3 PUFA, such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, would be hepatoprotective against the development of NAFLD by stimulating lipolysis ...

The lipid fraction of the grain sorghum whole kernel (GS-WK) (i.e., phytosterol rich oil or policosanol rich wax) responsible for lowering cholesterol in hamsters fed the crude lipid (wax + oil) was determined. As expected, hamsters fed an atherogenic diet for a four week period presented with higher plasma non-HDL plasma and liver esterified cholesterol than those on the low fat diet. However,...

This study was carried out to evaluate the adverse effects of exposure to prallethrin on oxidant/antioxidant status and liver dysfunction biomarkers and the protective role of Origanum majorana essential oil (EO) in rat. Male rats were divided into 4 groups: (i) received only olive oil (ii) treated with 64.0 mg/kg body weight prallethrin (1/10 LD₅₀) in olive oil via oral route daily for 28 days...

BACKGROUND & OBJECTIVES Our previous study showed that cow ghee relative to soybean oil had a protective effect against carcinogen induced mammary cancer in rats. The objective of this study was to elucidate its biochemical mechanism. METHODS Two groups of 21 day old rats (20 each) were fed for 44 wk diet containing cow ghee or soybean oil (10%). Five animals from each group were sacrificed a...

The aim of the present study was to investigate the effects of Moringa oleifera seed oil against acetaminophen-induced liver injury. 24 male Wistar albino rats were distributed into four treatment groups of six animals each and treatment lasted for ten days. Group1 animals were the Controls while the group2 animals received acetaminophen dosage (1g/Kg body weight) only on the tenth day. Group3 ...

OBJECTIVES To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage. METHODS This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was extracted using...

The objective of this study was to evaluate how the vehicles of choice affect the pharmacokinetics of orally administered Fluoranthene [FLA] in rats. Fluoranthene is a member of the family of Polycyclic Aromatic Hydrocarbon chemicals. Fluoranthene exposure to humans may occur as a result of cigarette smoking, consumption of contaminated food and water, heating woods in stoves and boilers, indus...

Studies show that inhalation of oil gas vapor may impose serious health risks for individuals exposed to such vapor. The main aim of this study was to determine the effects of diesel oil vapor inhalation on SGOT and SGPT as indices of liver function. Male Wistar rats were randomly divided into control animals, and rats that exposed to diesel oil vapor for 1 hour/day, for 2 hours/day and for 3 h...

The effect of various avocado oils on liver metabolism was studied in growing female rats. The rats were fed diets containing 10% (w/w) avocado oil for 4 wk. In comparison with rats fed refined avocado oil obtained from cored fruit by centrifugal separation, rats fed unrefined avocado oil obtained by organic solvent extraction from intact fruit, or its unsaponifiable components, showed a signif...