Liver metastasis (LM) frequently occurs in patients with advanced lung cancer; yet our understanding of the underlying salient biology is preliminary. Here, we performed single-cell RNA-seq three LM cancer and compared them hepatocellular carcinoma primary public database. Single cell RNA sequencing was on tissues from cancer. Also, downloaded TCGA GEO We applied Seurat to sort into different c...

background: 1, 2-dimethylhydrazine (dmh) enhances lipid peroxidation rate by tumor mitochondria than normal tissue counterpart and causes many disorders in antioxidant system in liver. it also increases the level of enzymes that metabolize toxin in liver and colon. the aim of this study was to evaluate the alteration of liver and its enzymes after dmh injection and evaluate protective effect of...

: The liver is one of the most common sites metastatic spread lung cancer, and process metastasis regulated by many factors. A number genes, including multiple tumor suppressor 1 (mts1), p120 catenin, CT45A1, increase possibility hepatic in whereas Tip30/CC3, CUL5, SOCS3 expression tumors inhibit metastasis. microRNAs (miRNAs), such as miRNA-126, miRNA-338, miRNA-218, can affect cancer cells to...

Background: Liver cancer is the second outstanding reason for cancer-related death global and thus a main public health challenge. Plant-based drugs are regarded as promising therapies. Basil and Dracocephalum kotschyi extracts have shown therapeutic impacts on various cancers. Therefore, we assessed the effects of the extract of Basil and Dracocephalum kotschyi on cell proliferation and BCL2 e...

the proliferation of hepatocellular carcinoma (hcc) cells is one of the leading causes of liver cancer mortality in humans. the inhibiting effects of matrine on hcc cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. since, apoptosis plays an important role in hcc cell proliferation. we examined the apoptosis-inducing effect of matrine on tu...

Arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As ...

background: a growing body of preclinical data indicates that statins may possess antineoplastic properties however, some studies have raised the possibility that statins may also have carcinogenic potential. methods: an air pouch model was used for angiogenesis. single or multiple applications of croton oil on the back of swiss albino mice with or without initiation by dimethylbenz(a)antherace...

widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. these protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. silymarin has cytoprotection activities due to its antioxid...

Background and objectives: To date, thousands of secondary metabolites have been isolated from plants and microorganisms and there is an unprecedented attention towards potential biomedical applications of natural compounds. In this study, cytotoxic properties of methanol extracts of Stachys obtusicrena, Aristolochia olivieri, Linum album, Dionysia sawyeri, Ajuga chamaecist...

aim : in this study, to clarify the smad4blocking impact on fibrosis process, we investigated its down-regulation by shrna on activated human lx-2 cell, in vitro.   background : liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (hcc).  different smad proteins play as major mediators in...