conclusions m30 levels were higher in cvhb patients compared to healthy controls. however, m30 levels were similar in the mild and moderate stages of fibrosis, so they did not indicate the severity of underlying fibrotic or inflammatory processes in cvhb patients. results the mean ages of patients and controls were 39.7 and 45.7 years, respectively, and 35% of the controls and 52% of the patien...

currently, hematopoietic stem cell transplantation (hsct) is the only curative option for patients with beta-thalassemia major, but liver iron overload in these patients will not decrease and hepatic fibrosis may still progress despite successful hsct. liver biopsy samples were taken from 14 patients (out of 25 patients) who underwent hsct. all patients met three criteria: negative hcv antibody...

conclusions use of ha in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of ha as an appropriate clinical tool. results there are several scientific studies indicating ha as a biomarker for high score fibrosis and cirrhosis in various liver diseases alon...

Liver biopsies are traditionally performed to determine the cause and stage of liver disease, as well as to inform treatment decisions and determine prognosis. In 2001, Bravo et al. observed that “liver biopsy is usually the most specific test to assess the nature and severity of liver diseases.”1 During the past 16 years, however, the clinical use of liver biopsies has undergone a profound tra...

liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and non-alcoholic fatty liver disease. in the course of the chronic liver disease, hepatic fibrogenesis may develop, which is attributed to various types of cells, molecules, and pathways. activated hepatic stellate cell (hsc), the primary ...

Objective: Recent reports have shown that liver stiffness measurement using Fibroscan allowed accurate prediction of hepatic fibrosis in patient with chronic hepatitis C but few reports are published for chronic hepatitis B especially in Egypt. The study aimed to compare and validate the results of fibroscan versus liver biopsy among chronic HBV patients who are not candidates for treatment acc...

At the present time, pathological examination of a liver fragment obtained by liver biopsy remains an essential diagnostic tool of numerous chronic liver diseases [1] Indications for liver biopsy (LB) have changed considerably over recent years due to the development of sensitive and specific tests for diagnosis of several chronic liver diseases (i.e., serology for hepatitis C, antimitochondria...

Ultrasound-guided percutaneous biopsy of visceral organs in the abdomen has been in effect for many years. Paul Ehrlich is credited with performing the first percutaneous liver biopsy in 1883 in Germany. Schüpfer in 1907 published the first liver biopsy series. Huard and Baron popularized liver biopsy for general purposes in the1930s. Some of the more contemporary articles reporting ultrasound-...

Assessment of liver histology following orthotopic liver transplantation is an essential component of management in the transplant recipient. Most programs recommend liver biopsies when there are changes in the patient’s status or biochemical tests. The use of protocol allograft biopsies, that is in asymptomatic recipients with normal or near-normal liver tests, is controversial. Considerations...