1. Recognition that inositol phospholipid-derived second messengers are involved in the initiation and maintenance of airway smooth muscle contraction raises the possibility of new therapeutic approaches to the treatment of asthma. We anticipated that lithium, through its effects on cell signal transduction and ion-transport pathways, would be likely to protect the airways against constrictor s...

Lithium is a well-known treatment for patients with mood disorders. Intoxication by lithium may be lethal particularly in elderly due to altered pharmacokinetics, renal impairment or multiple drug use. We presented a 74-year-old female patient who had been stabile with lithium carbonate 600 mg/day for 5 years and developed lithium intoxication after bronchiolitis. She presented with altered men...

Drug-induced mental disturbances are frequent in bone marrow transplantation (BMT) patients who require numerous kinds of drugs. Although steroid-induced mental disorder is common in BMT settings, its treatment has not been fully investigated. We encountered a patient with acute myeloid leukemia who developed depressive disorder induced by steroid given for graft-versus-host disease treatment. ...

The electrochemical performance of a Ti Ni Nb electrode in different solutions has been studied. The Ti Ni Nb electrode can 46 45 9 46 45 9 Ž Ž . absorbrdesorb hydrogen in 3 M KOH aqueous and lithium in non-aqueous solution 1 M LiClO dissolved in a 50r50 vol.% vro 4 . mixture of ethylene carbonate and diethyl carbonate , respectively. It is assumed that lithium and hydrogen are incorporated in ...

Lithium was investigated for its possible use as a marker for identifying the various sources of NaCl in the diet. Micromolar concentrations of lithium can be detected in various vegetables, tap water and also in urine specimens of adult volunteers. The lithium content of vegetables varied from 6.1 to 24.5 mumol of lithium/kg dry weight, with the exception of spinach and aubergines which had mu...

R a series of ecological studies1–7 on antisuicidal properties of naturally occurring lithium contents in drinking water have sparked interest among researchers. In this issue, Ishii and colleagues8 present further argument for the hypothesis that even low lithium doses—or rather, doses of lithium at a supplemental level—might have their place in suicide prevention. With limitations, there is s...

OBJECTIVE Lithium users are offered routine renal monitoring but few studies have quantified the risk to renal health. The aim of this study was to assess the association between use of lithium carbonate and incidence of renal failure in patients with bipolar disorder. METHODS This was a retrospective cohort study using the General Practice Research Database (GPRD) and a nested validation stu...

The objective of this work was the development and validation of atomic absorption spectrometric (AAS) methods for the determination of residual active pharmaceutical ingredients (API) in rinse samples for cleaning validation. AAS as an indirect method for the determination of API in rinse samples can be applied when it is in the form of salt with metal ions or when the metal ion is a part of t...

In a group of patients suffering from manic depressive illness treated with lithium carbonate occasional large increases in creatine phosphokinase (C.P.K.) activity were seen. These were found to occur at times when the patients were stable in mood and clinically well. The serum lithium levels were adequate in all cases at the time of raised C.P.K. activity. Raised C.P.K. activity can be an ind...