Cocaine, as an indirect dopamine agonist, induces selective behavioral and physiological events such as hyperlocomotion and dopamine release. These changes are considered as consequences of cocaine-induced molecular adaptation such as CREB and c-Fos. Recently, methanolic extracts from licorice was reported to decrease cocaine-induced dopamine release and c-Fos expression in the nucleus accumben...

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-infl...

The global demand for herbal cosmetics is vastly increasing due to their health benefits and relative safety. Glycyrrhiza spp. extracts are used in cosmetic preparations skin-whitening, antisensitizing, anti-inflammatory properties. aim of this work computationally evaluate the bioactive constituents licorice (Glycyrrhiza glabra L.) that possess antioxidant, anti-inflammatory, dermatocosmetic a...

Abstract Polymethoxylated flavones (PMFs), the main form of in citrus, are derived from flavone branch flavonoid biosynthesis pathway. Flavone synthases (FNSs) enzymes that catalyze synthesis flavanones. However, FNS citrus has not been characterized yet. Here, we identified two type II FNSs, designated CitFNSII-1 and CitFNSII-2, based on phylogenetics transcriptome analysis. Both recombinant C...