the present study was conducted to test the effect of origanum majoranum extract (ome) of leaves on alterations induced in a model of type 2 diabetic rats. adult male wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. diabetic rats were given aqueous extract of ome in a dose of 20 mg/kg orally ...

Anthranilic acid analogues and their derivatives hold significant therapeutic potential for crafting designed compounds aimed at regulating cancer-causing pathways addressing metabolic challenges linked to diabetes, antiviral agents [...]

background: obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. glutamate decarboxylase 2 (gad2) gene is associated with obesity and it regulate food intake and insulin level. we investigated the association of gad-2gene −243a>g (rs2236418) and +61450c>a (rs992990) polymorphisms with obesity and related phenotypes. methods: insulin, glucose and lipid lev...

In eukaryotic cells, the membranes of different intracellular organelles have different lipid composition, and various biomembranes show an asymmetric distribution of lipid types across the membrane bilayer. Membrane lipid organization reflects a dynamic equilibrium of lipids moving across the bilayer in both directions. In this review, we summarize data supporting the role of specific membrane...

The protective machinery of the skin opposes external agents by barrier and innate adaptive immunity. local interplay in epithelial-immune microenvironment (EIME) contributes to situation-specific protective/inflammatory responses, its dysregulation generates inflammatory loops atopic dermatitis psoriasis. Keratinocytes are key player EIME. However, a common regulator keratinocyte response this...

Background: Peroxisome proliferator-activated receptors (PPARs) have a pivotal role in regulating genes that are involved in lipid