introduction: the impact of chromium exposure was studied on liver, kidney, testis, spleen, cerebrum and cerebellum of male wistar rats (80-100 g body weight). material & method: it was observed that treatments of rats with chromium (i.p. at a dose of 0.8 mg / 100 g body weight per day) for a period of 28 days caused significant increase in chromium content while declining the body weight along...

A fundamental objective in membrane biology is to understand and predict how a protein sequence folds and orients in a lipid bilayer. Establishing the principles governing membrane protein folding is central to understanding the molecular basis for membrane proteins that display multiple topologies, the intrinsic dynamic organization of membrane proteins, and membrane protein conformational dis...

Alterations in erythrocytes from Alzheimer disease patients were examined using EPR spectroscopy. Three spin-labeled fatty acids were applied to measure lipid membrane fluidity. A decrease of membrane fluidity was found in the deeper region of lipid bilayer of erythrocytes membrane, as indicated by 12-doxylstearic acid assay. The physical state of erythrocyte membrane proteins was estimated usi...

The eukaryotic cortical actin cytoskeleton creates specific lipid domains, including lipid rafts, which determine the distribution of many membrane proteins. Here we show that the bacterial actin homologue MreB displays a comparable activity. MreB forms membrane-associated filaments that coordinate bacterial cell wall synthesis. We noticed that the MreB cytoskeleton influences fluorescent stain...

Synthetic transducers transport externally added metal ion cofactors across the lipid bilayer membrane of vesicles to trigger catalysis ester hydrolysis in inner compartment. Signal transduction activity is modulated by hydrazone formation.

There has been exponential growth in the number of membrane protein structures determined. Nevertheless, these structures are usually resolved in the absence of their lipid environment. Coarse-grained molecular dynamics (CGMD) simulations enable insertion of membrane proteins into explicit models of lipid bilayers. We have automated the CGMD methodology, enabling membrane protein structures to ...

Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic membrane-based system has evolved to sustain wealth structural reorganizations in order accomplish its biophysical function, as it coats stabilizes the respiratory air-liquid interface mammalian lung. The present review dissects complexity structure-function relationships LS through updated description lipid-pr...