metabolic myopathies are genetically inherited disorders of muscle energy production that result in skeletal muscle dysfunction. they are a large group of diseases with diverse inborn errors of metabolism, in particular muscle energy production, and including disorders of glycogen (lysosomal and non-lysosomal glycogenoses), lipid (disorders of fatty acid b-oxidation, primary carnitine deficienc...

CE Full-text articles and CE testing at CompendiumVet.com.Send comments/ questions via email compendium@ medimedia.com, fax 800-556-3288, or web CompendiumVet.com. Lipid disorders are common in dogs, with most arising from secondary causes such as endocrine imbalances, cholestatic liver disease, or protein-losing nephropathies.Two primary lipid disorders—idiopathic hyperlipidemia in miniature s...

Some ideas are many years ahead of their time. In the last quarter of the nineteenth century, Thudichum, one of the founding fathers of neurochemistry, studied the composition of the brain. (For reviews of Thudichum’s work and his contributions to the development of neurochemistry, see Sourkes). His aim was to determine the composition of the brain, as far as was possible, in order to discover ...

Lipid evaluation in a diabetic paticnt begins with averaging several measurements of blood sugar, total cholesterol. triacylglycerol and high-density lipoprotein (HDL) cholesterol after a 1 2 h fast. Patients with non-insulin-dependent diabetes may have any one of several of lipid disorders [ 1 I, but typically diabetic dyslipidaemias share the characteristics of high very-low-density lipoprote...

Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] cholesterol) or nephropathy (increased triglycerides and LDL cholesterol, low level of high density lipoprotein [HDL] cholesterol). In cases of T1D with optimal...

INTRODUCTION Chronic kidney disease (CKD) represents a serious public health problem due to the increase in incidence and prevalence of this disease worldwide. Given the significant morbidity and mortality from cardiovascular disease (CVD) in the population of patients with CKD, and the fact that dyslipidemia itself is a risk factor for CVD, increases the importance of lipid metabolism study in...

statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of hmg-co a reductase. apart from the well-known ldl and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. better understanding of various pleotropic effects of statins has prompted a new s...

Lysosomes are acidic compartments in mammalian cells that are primarily responsible for the breakdown of endocytic and autophagic substrates such as membranes, proteins, and lipids into their basic building blocks. Lysosomal storage diseases (LSDs) are a group of metabolic disorders caused by genetic mutations in lysosomal hydrolases required for catabolic degradation, mutations in lysosomal me...