Borrelia sp. B(2)5, when grown in a medium containing [1-(14)C] linoleic acid in an atmosphere of CO(2), was found to hydrogenate linoleic acid to trans-11-octadecenoic acid.

BACKGROUND/AIM To comparatively investigate the effects of linoleic acid on convulsive and nonconvulsive epileptic seizures. MATERIALS AND METHODS Rats were divided into 3 groups: convulsive epileptic rats receiving only pentylentetrazole (PTZ) injections (group 1), convulsive epileptic rats receiving PTZ and linoleic acid (group 2), and Wistar Albino Glaxo rats from Rijswijk with genetic abs...

The antioxidative activity of α-tocopherol and Trolox, a water-soluble carboxylic acid derivative of α-tocopherol, in an emulsion stabilized with the hydrophilic emulsifier, polyoxyethylene (20) sorbitan monolaurate, was evaluated by measuring the changes in linoleic acid content, peroxide value, and thiobarbituric acid value. The activity of α-tocopherol and Trolox to depress the autoxidation ...

SCOPE Conjugated linoleic acids are linoleic acid isomers found in the diet that can also be produced through bacterial metabolism of polyunsaturated fatty acids. Our objective was to evaluate the contribution of fatty acid metabolites produced from polyunsaturated fatty acids by the gut microbiota in vivo to regulation of hepatic lipid metabolism and steatosis. METHODS AND RESULTS In mice wi...

We have previously demonstrated that oral administration of a metabolically active Bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (CLA), resulted in modulation of the fatty acid composition of the host, including significantly elevated concentrations of c9, t11 CLA and omega-3 (n-3) fatty acids in liver and adipose tissue. In this study, we investiga...

OBJECTIVE To determine the effect of oleic acid and linoleic acid on the production and secretion of specific diabetic retinopathy- (DR-) related cytokines: vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and interleukin-8 (IL-8) by human retinal glial cells, retinal endothelial cells, and retinal pigment epithelial cells. These expression profiles will be compared to those obt...

Pseudo-acylceramides with different acyl properties were investigated for their capacity to restore diminished barrier function in essential fatty acid-deficient rats. Daily topical applications of synthetic pseudo-acylceramides containing ester-linked linoleic acid caused a dose-dependent, significant reduction of transepidermal water loss (TEWL). Both other pseudo-acylceramides with ester-lin...

1. Since several lines of evidence have suggested that a diminution of endogenous prostaglandins (PG) may participate in the pathogenesis of a variety of disease states, it would be advantageous to develop therapeutic approaches that augment endogenous prostaglandin synthesis. Since linoleic acid is readily converted to arachidonic acid, we assessed the effects of linoleic acid administration o...

We investigated the effect of different interventions on aortic atherosclerosis in Watanabe rabbits. Four groups of rabbits were fed either an oleic acid-enriched diet (80% of total fat intake) with or without vitamin E supplementation (250 IU/kg) or a diet enriched in linoleic acid with or without vitamin E supplementation for 6 months. At the start of the study, plasma cholesterol concentrati...

Gas chromatographic determination of the fat ty acids in the seeds of soybean (Glycine max) showed mainly linoleic, oleic and palmitic acids with linoleic acid being the major component . Changes in the distribution of fat ty acids were measured during germination in the cotyledons and roots. A decrease in palmitic and oleic acids was observed in the cotyledons from 6 to 12 days, while linoleic...