Although sex-linkage in animals is no longer an unusual phenomenon, its apparent rarity in rodents is noteworthy, especially in the intensively studied house mouse and rat. Hauschka, et al.,1 have presented evidence for a sex-linked lethal altering the sex ratio in the house mouse; Falconer2 recently reported a second sex-linked mutation in the house mouse. A third sex-linked mutation, Bent-tai...

Autosomal dominant hypophosphatemic rickets (ADHR) is an inherited disorder of isolated renal phosphate wasting, the pathogenesis of which is unknown. We performed a genome-wide linkage study in a large kindred to determine the chromosome location of the ADHR gene. Two-point LOD scores indicate that the gene is linked to the markers D12S314 [Z(theta) = 3.15 at theta = 0.0], vWf [Z(theta) = 5.32...

incontinentia pigmenti (ip) is an uncommon x-linked dominant genodermatosis characterized by four cutaneous stages and frequent association with dental (90%), central nervous system (33%) and ocular (35%) anomalies. the exact pathogenesis of this disorder remains unknown. herein, we report a newborn girl with inflammatory vesiculobullous and warty skin lesions and a positive family history of i...

objective hereditary spastic paraplegia (hsp) is a degenerative disease of genetic origin affecting the corticospinal tracts in the spinal cord. there are three forms of inheritance: autosomal dominant hsp, autosomal rececive hsp and x-linked hsp. this disease is characterized by progressive spasticity of leg muscles with varying degrees of stiffness and weakness of other muscle groups. in this...

the identification of molecular markers linked to leaf curl virus (clcuv) disease resistance in cotton has the potential to improve both the efficiency and the efficacy of selection in cotton breeding programs. genetic analysis suggested that clcuv resistance is controlled by a single dominant gene. in this study, an interspecific f2 population derived from a cross of gossypium barbadense and g...