نتایج جستجو برای: link disruption
تعداد نتایج: 249927 فیلتر نتایج به سال:
OBJECTIVE Patients with Attention-Deficit/Hyperactivity Disorder (ADHD) have a high prevalence of obesity. This is the first study to investigate whether circadian rhythm disruption is a mechanism linking ADHD symptoms to obesity. METHODS ADHD symptoms and two manifestations of circadian rhythm disruption: sleep problems and an unstable eating pattern (skipping breakfast and binge eating late...
Multipath routing has been proposed to increase resilience against network failures or improve security in Mobile Ad-Hoc Networks (MANETs). The Optimized Link State Routing (OLSR) protocol has been adopted by several multipath routing strategies. They implement Multipoint Relay (MPRs) nodes as a flooding mechanism for distributing control information. Ideally, the construction of multiple disjo...
1 School of Electronics and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China 2Phillip M. Drayer Department of Electrical Engineering, Lamar University, Beaumont, TX 77710, USA 3Department of Electronics and Information Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong 518055, China 4NEC Europe Ltd., NEC Laboratories Europe, Kurfü...
Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms [2]. However, mechanistic basis for this association remains unknown. Therefore, we investigated the circadian phenotype of blind-drunk (Bdr), a mouse model of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays sc...
According to behavioral momentum theory, preference and relative resistance to change in concurrent-chains schedules are correlated and reflect the relative conditioned value of discriminative stimuli. In the present study, we explore the generality of this relation by manipulating the temporal context within a concurrent-chains procedure through changes in the duration of the initial links. Co...
Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link
Sleep is a vital phenomenon related to immunomodulation at the central and peripheral level. Sleep deficient in duration and/or quality is a common problem in the modern society and is considered a risk factor to develop neurodegenerative diseases. Sleep loss in rodents induces blood-brain barrier disruption and the underlying mechanism is still unknown. Several reports indicate that sleep loss...
Conditional gene deletion in mice has contributed immensely to our understanding of many biological and biomedical processes. Despite an increasing awareness of nonprotein-coding functional elements within protein-coding transcripts, current gene-targeting approaches typically involve simultaneous ablation of noncoding elements within targeted protein-coding genes. The potential for protein-cod...
JEM © The Rockefeller University Press $15.00 Vol. 204, No. 3, March 19, 2007 571–582 www.jem.org/cgi/doi/10.1084/jem.20061931 571 powerful target for therapeutic intervention (4), the mechanisms of perivascular microglia activation in infl ammatory demyelination as well as a strategy to limit their activation in MS have not been identifi ed. In MS lesions, perivascular activation of microglia ...
Hubs are centers for collection, rearrangement, and redistribution of commodities in transportation networks. In this paper, non-linear multi-objective formulations for single and multiple allocation hub maximal covering problems as well as the linearized versions are proposed. The formulations substantially mitigate complexity of the existing models due to the fewer number of constraints and v...
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