To investigate the biological effects of nonuniform distribution of radioactivity in mammalian cells, we have developed a novel three-dimensional tissue culture model. Chinese hamster V79 cells were labeled with tritiated thymidine and mixed with unlabeled cells, and multicellular clusters (approximately 1.6 mm in diameter) were formed by gentle centrifugation. The short-range beta particles em...

Pure water has been used to dechlorinate aliphatic organics without the need for catalysts or other additives. Dehydrohalogenation (loss of HCI with the formation of a double bond) occurred at temperatures as low as 105-200 degrees C for 1,1,2,2-tetrachloroethane, lindane (1,2,3,4,5,6-hexachlorocyclohexane, gamma-isomer), and dieldrin (1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahy...

The protective effect of fresh aloe vera (AV) leaves extract on lindane (LD) - induced hepatoxicity and genotoxicity was studied. Serum levels of hepatic enzyme markers: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were determined after oral administration of aloe vera leaves extract and lindane...

Diagnosis of scabies in young children can be challenging since the morphology and distribution of skin lesions may differ from adults. Therefore, clinicians should keep scabies in mind in their differential diagnosis in a child who presents with severe pruritic, polymorphic skin lesions. Regarding the treatment of scabies, the reported clinical experience with gamma benzene hexachloride (linda...

Among all classes of synthetic pesticides, organochlorines have found indiscriminate applications in the last century. DDT (dichlorodiphenyltrichloroethane) and HCH (hexachlorocyclohexane) were the major OCP (organochlorine pesticides) used by many developed and developing countries. Lindane (HCH) and DDT were detected in the water, sediments and biota of certain provinces in China even after ...

Gap junctional intercellular communication (GJIC) is essential in the maintenance of tissue homeostasis and has been implicated in tumor suppression. Recent studies have indicated that GJIC is also involved in cellular stress responses to low dose ionizing radiation, UV light and hydrogen peroxide. However, the contribution of GJIC to the heat stress response has not yet been elucidated. We her...

A thin, healthy, partial-vegetarian, white female, who was exposed to three doses of lindane (through the application of Kwell), developed a severe case of long-term lindane poisoning. Review of the literature suggests that her toxicity was so severe because of the repetitive nature of her exposure and the fact that she was partly protein restricted when first exposed. She developed profound ce...

Lindane (g-hexachlorocyclohexane) is an organochlorine pesticide and a Persistent Organic Pollutant (POP). Lindane residues have been detected in drinking water sources and development of viable methods for their removal is a global priority. Iron based nanomaterials have been shown to effectively transform chlorinated organic compounds. However, their uses in the treatment of drinking water an...

Oral administration of low doses (0.0625, 0.125, or 0.25 mg/kg body weight, po, corresponding to 1/1400th, 1/700th, or 1/350th of LD(50), respectively) of lindane, an organochlorine insecticide, to pregnant dams from gestation day 5-21 was found to produce dose-dependent alterations in the ontogenic profile of xenobiotic-metabolizing cytochrome P450s (CYPs) in the brain and liver of offspring. ...

Adult laying domestic ducks (Anas platyrhynchos domesticus) were forced fed lindane (gamma-hexachlorocyclohexane) 20 mg/kg body weight daily, thrice/week and twice/week for 8 weeks. Significant shell thinning (18-21%) was observed in ducks with daily and thrice/week lindane feeding. SEM studies of thinned eggshells revealed reduced and tightly clustered mammillae with apparent decrease in inter...