Cortico-striato-thalamo-cortical (CSTC) loops project from the cortex to the striatum, then from the striatum to the thalamus via the globus pallidus, and finally from the thalamus back to the cortex again. These loops have been implicated in Obsessive-Compulsive Disorder (OCD) with particular focus on the limbic CSTC loop, which encompasses the orbitofrontal and anterior cingulate cortices, as...

The limbic system mediates memory, behavior, and emotional output in the human brain, and is implicated in the pathology of Alzheimer's disease and a wide spectrum of related neurological disorders. In vivo magnetic resonance imaging (MRI) of structural components comprising the limbic system and their interconnections via white matter pathways in the human brain has helped define current under...

OBJECTIVE Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans. METHOD Using positron emission tomography, the researchers measured relative regional cerebral blood flow (CBF) in limbic and comparison brain regions of 14 detoxified male co...

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The subject of the limbic system is old anatomically, but very new from the point of view of our knowledge of its function-indeed, so new that many of the more important disclosures have been made within the last two years. These recent advances have a direct bearing on many branches of clinical medicine and are of immediate importance both to the general physician and to the neurologist. The l...