نتایج جستجو برای: light transmittance aggregometry

تعداد نتایج: 400946  

2013
Rolf P Kreutz Janelle Owens Yan Jin Perry Nystrom Zeruesenay Desta Yvonne Kreutz Jeffrey A Breall Lang Li ChienWei Chiang Richard J Kovacs David A Flockhart

Recent candidate gene studies using a human liver bank and in vivo validation in healthy volunteers identified polymorphisms in cytochrome P450 (CYP) 3A4 gene (CYP3A4*22), Ah-receptor nuclear translocator (ARNT), and peroxisome proliferator-activated receptor-α (PPAR-α) genes that are associated with the CYP3A4 phenotype. We hypothesized that the variants identified in these genes may be associ...

Journal: :The Journal of pharmacology and experimental therapeutics 2011
Patrick André Francis DeGuzman Helena Haberstock-Debic Scott Mills Yvonne Pak Mayuko Inagaki Anjali Pandey Stanley Hollenbach David R Phillips Pamela B Conley

Clinical studies with clopidogrel or prasugrel show that although increased inhibition of P2Y(12) and platelet function improves efficacy, bleeding is also increased. Other preclinical and clinical studies have suggested a greater therapeutic index (TI) with reversible inhibitors and disproportionate effects of thienopyridines on bleeding at high doses. We used multiple in vivo (FeCl(3)-induced...

2012
Rolf P Kreutz Perry Nystrom Yvonne Kreutz Jia Miao Zeruesenay Desta Jeffrey A Breall Lang Li ChienWei Chiang Richard Kovacs David A Flockhart Yan Jin

BACKGROUND The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard to (1) the association of a common polymorphism of PON1 (Q192R) with reduced rates of coronary stent thrombosis in patients takin...

Journal: :Journal of atherosclerosis and thrombosis 2014
Koichi Kaikita Takamichi Ono Satomi Iwashita Naoki Nakayama Koji Sato Eiji Horio Shinichi Nakamura Kenichi Tsujita Shinji Tayama Seiji Hokimoto Tomohiro Sakamoto Koichi Nakao Shuichi Oshima Seigo Sugiyama Hisao Ogawa

AIM Carriers of the reduced-function CYP2C19 allele receiving dual antiplatelet therapy (DAPT) with aspirin and clopidogrel exhibit diminished platelet inhibition and an increased risk of events. The purpose of this study was to investigate the effects of CYP2C19 gene variants on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing elective percutaneous cor...

Journal: :The American naturalist 2016
David C Lahti Daniel R Ardia

The vibrant colors of many birds' eggs, particularly those that are blue to blue-green, are extraordinary in that they are striking traits present in hundreds of species that have nevertheless eluded evolutionary functional explanation. We propose that egg pigmentation mediates a trade-off between two routes by which solar radiation can harm bird embryos: transmittance through the eggshell and ...

Journal: :European heart journal 2008
Dominick J Angiolillo Piera Capranzano Shinya Goto Mohammed Aslam Bhaloo Desai Ronald K Charlton Yoshie Suzuki Lyndon C Box Steven B Shoemaker Martin M Zenni Luis A Guzman Theodore A Bass

AIMS Patients with type 2 diabetes mellitus (T2DM) have reduced platelet inhibition compared with non-diabetics following P2Y(12) receptor blockade. Whether inhibition of P2Y(12) signalling can be enhanced by adjunctive treatment with cilostazol in T2DM patients is unknown. The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clo...

2016
Shuhua Li Jae-Lim Choi Long Zhe Guo Ri-Young Goh Bo-Ram Kim Kwang-Sook Woo Moo-Hyun Kim Jin-Yeong Han

BACKGROUND An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200 System; Siemens Healthcare, Germany) P2Y test. METHODS Polymorphisms of CYP2C19*2, *3, *17 and the degree of inhibition of platelet function were determ...

2009
Goran Rudež Nicole A.H. Janssen Evren Kilinc Frank W.G. Leebeek Miriam E. Gerlofs-Nijland Henri M.H. Spronk Hugo ten Cate Flemming R. Cassee Moniek P.M. de Maat

BACKGROUND Air pollution has consistently been associated with increased morbidity and mortality due to respiratory and cardiovascular disease. Underlying biological mechanisms are not entirely clear, and hemostasis and inflammation are suggested to be involved. OBJECTIVES Our aim was to study the association of the variation in local concentrations of airborne particulate matter (PM) with ae...

2010
Lin Wang Xiaobei Wang Fenghua Chen

BACKGROUND There are limited prospective data on clopidogrel resistance and clinical outcome of patients with selective coronary drug-eluting stent (DES) implantation. OBJECTIVE To investigate whether clopidogrel resistance is associated with long-term thrombotic events in patients with selective coronary DES implantation. METHODS A total of 154 patients who underwent selective percutaneous...

2016
Yong-Pu Zhang Shu-Ran Li Jun Ping Shi-Wen Li Hua-Bin Zhou Bao-Jun Sun Wei-Guo Du

Light is an environmental factor that is known to profoundly affect embryonic development in some oviparous vertebrates, but such effects are unstudied in reptiles. We investigated the light sensitivity of lizard embryos by examining the thickness and light transmittance of eggshells as well as the effect of light on embryonic development and hatchling traits in four lizard species, the Chinese...

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