A total of 333 patients arriving within 6 h of the onset of suspected or proven but uncomplicated myocardial infarction were randomized to treatment by either the prophylactic or the selective lidocaine strategy. Patients were monitored for 24 h. The major end points were sustained ventricular tachycardia or fibrillation and emergent adverse effects of lidocaine. There were four episodes of eme...

Introduction: The aim of this study was to study if lidocaine exhibits a toxic effect on bovine-derived nucleus pulposus (NP) cells in an in vitro study. Provocative discography is utilized by some physicians in the evaluation of back pain that may be discogenic in origin, and some variations of the technique suggest infiltration of lidocaine into the outer anulus fibrosus prior to intradiscal ...

BACKGROUND Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine. We investigated the hypotheses that these drugs (A) are less neurotoxic than the prototype local anesthetic, lidocaine ...

Editor—We read with interest the case report by Satsumae and colleagues, addressing the question of sensitivity to local anaesthetics (LAs) with toxicity occurring at a lower than expected dose. We encountered a similar case in a 51-yr-old woman who presented with generalized myoclonic movements after a popliteal-sciatic blockade with a non-stimulating catheter, inserted with a peripheral nerve...

In general, much greater doses of local anesthetics are required to produce cardiovascular (CV) toxicity than CNS toxicity. Similar to CNS toxicity, potency for CV toxicity reflects the anesthetic potency of the agent. Recent attention has focused on the apparently exceptional cardiotoxicity of the more potent, more lipid-soluble agents (bupivacaine, levo-bupivacaine, etidocaine, ropivacaine). ...

ous infusion of1% lidocaine hydrochloride at a dose of 1 mg/kg/h. A posterior parietal pleural pocket was created and cannulated with a 16-g polyethylene catheter. Lidocaine was perfused over a 3-day period following surgery. Patients also had access to mor¬ phine sulfate via patient-controlled analgesia. Eigh¬ teen consecutive posterolateral thoracotomies (in 17 patients) performed during a 6-...

Local anesthetic toxicity is a recognized clinical problem that has limited the use of topical corneal anesthetics for pain relief after corneal abrasion. Studies have shown clinically administered concentrations (0.5-2%) of local anesthetics impair corneal reepithelialization. Unfortunately, instillation of local anesthetic drops into an eye does not provide a measurable, steady-state concentr...