BACKGROUND AND PURPOSE Patients with extensive leukoaraiosis are at high risk for vascular dementia. However, these patients exhibit variable severity of global cognitive impairment correlating with callosal atrophy. We hypothesized that callosal atrophy may reflect the severity of HDWM tract damage, which may explain global cognitive impairment. The purpose of this study was to evaluate HDWM t...

BACKGROUND AND PURPOSE We investigated the hypothesis that patients with one or more asymptomatic lacunar infarcts and those with only one symptomatic lacunar infarct represent two clinically distinct lacunar infarct entities. METHODS In a prospective series of 100 lacunar infarct patients, univariate and multivariate logistic regression analysis was performed on clinical features, vascular r...

OBJECTIVE To localize susceptibility genes for alterations in brain structure associated with risk of stroke and dementia. We conducted genomewide linkage analyses for magnetic resonance imaging (MRI) measures of brain atrophy, ventricular, and subcortical white matter hyperintensity (leukoaraiosis) in 689 non-Hispanic white (673 sibling pairs; median age, 61 years) and 544 non-Hispanic black p...

OBJECTIVE White matter hypoperfusion may play a part in the pathogenesis of ischaemic leukoaraiosis, but demonstration of this requires a high resolution quantitative method of cerebral blood flow (CBF) measurement. Initial exogenous contrast based MRI methods only allowed measurement of relative cerebral blood volume (CBV) values, but more recently a mathematical approach has been developed wh...

To explore the risk factors of bleeding transformation and poor 90 d prognosis in acute cerebral infarction patients after emergency thrombolysis. A total 576 treated with thrombolytic therapy department from July 2018 to February 2021 were analyzed retrospectively. They divided into groups according treatment, including 92 244 prognosis. The general data, treatment-related indicators laborator...

Leukoaraiosis is a neurological imaging in the periventricular area and centrum semiovale. This condition occurs due to abnormalities small blood vessels brain that lead hypoxia. It often observed patients with ischemic stroke accompanied by risk factors for hyperlipidemia. study aimed evaluate correlation between degree of leukoaraiosis hyperlipidemia post-ischemic patients. A cross-sectional ...

We studied 33 consecutive patients with computed tomographic findings of decreased density in the periventricular white matter (leukoaraiosis). Computed tomograms in five (aged 56-75 years) of the 33 demonstrated intracerebral hematoma. The hemorrhages were situated in the thalamic area in four and in the parietotemporal area in one patient. These five patients were hypertensive and had signs c...

BACKGROUND Hypercoagulability is observed in vascular dementia, including Binswanger disease. However, the correlation between hypercoagulability, leukoaraiosis, and dementia remains unclear. OBJECTIVE To examine how activation of the coagulation fibrinolysis correlates with leukoaraiosis and dementia. PATIENTS AND METHODS Thrombin-antithrombin complex (TAT), prothrombin fragment(1 + 2) (F1...

BACKGROUND AND PURPOSE Age-related white matter disease (leukoaraiosis) clusters in bands in the centrum semiovale, about the occipital and frontal horns of the lateral ventricles, in the corpus callosum, and internal capsule. Cerebrovascular anatomy suggests that some of these locations represent border zones between arterial supply territories. We hypothesized that there are zones of reduced ...