Abstract Studies of acute myeloid leukemia rely on DNA sequencing and immunophenotyping by flow cytometry as primary tools for disease characterization. However, tumor heterogeneity complicates integration variants immunophenotypes from separate measurements. Here we introduce DAb-seq, a technology simultaneous capture genotype cell surface phenotype single cells at high throughput, enabling di...

CAR T cell therapy is a promising immunotherapy that can target and eradicate leukemia cells with high specificity. While CD19, CD20, CD22 have shown impressive responses in ALL patients

Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have d...

Background: Cancer is a public health emergency. It has high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence still unclear. Thus, this systematic review aims summarize regarding use of CAR-NK as therapy for Method...

Abstract Resistance remains the major clinical challenge for therapy of Philadelphia chromosome–positive (Ph+) leukemia. With exception ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit common “gatekeeper” mutation T315I. Here we investigated therapeutic potential crizotinib, a TKI targeting ALK and ROS1 in non-small cell lung cancer patients, which inhibited also ...

APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α+ and CD103+ dendritic cells (DCs), in particular, required spontaneous initiation CD8+ priming against solid tumors. In contrast, little is known about that regulate responses hematological malignancies. Using an unbiased approach, we aimed to characterize responsible regu...

K-means transformation, histogram equalization, linear contrast stretching, and share-based features are all used to detect leukemia. A method for automatically classifying leukocytes using microscopic images is proposed. This proposed model MATLAB find leukemia cells in healthy blood cells, it requires no medical equipment or expert heavily relies on automation. technology can anemia, malaria,...

Objective: Lymphoid enhancer-binding factor-1 (LEF1) is one of the key regulators lymphocyte proliferation and its aberrant expression a prognostic factor for lymphoid or myeloid malignancies. In this study, we focused on LEF1 isoforms in several hematological malignancies found tissue-specific differential full-length (FL)-LEF1 gene tumor suppressor (∆LEF1) variant. Material Method: Fifty-thre...

regulation of normal cell growth and turnover is balanced between cell pro¬liferation, cell differentiation and apoptosis. a disruption of this balance is thought to be an important event leading to carcinogenesis .one of the effector molecules in apoptosis is fas antigen . cross-linking of fas by its ligand (fas l) or agonistic anti fas antibodies induces apoptosis of cells expressing fas on t...