This study was carried out on fish channa punctatus to investigate the lethal concentration of cadmium nitrate at 24 hr. Experiment procedure repeated five times selected concentrations, noting number killed. The mean value taken. These values were taken determine LC50 for Toxicity heavy metals it may be depends upon dose and time exposure period.

The developmental toxicity of silver nanoparticles (AgNPs) was investigated following exposure of Oryzias latipes (medaka) embryos to 0.1-1 mg/L of homogeneously dispersed AgNPs for 14 days. During this period, developmental endpoints, including lethality, heart rate, and hatching rate, were evaluated by microscopy for different stages of medaka embryonic development. To compare toxic sensitivi...

Marrow cells from previously established lines of transgenic mice expressing either of two different methotrexate (MTX)-resistant dihydrofolate reductases (DHFRs) were transplanted into recipient animals to determine the resultant in vivo protective effect against toxicity associated with MTX administration. Sublethally irradiated, untransplanted animals were first used to establish conditions ...

Toxicity testing is conducted to determine the potential human health hazards of chemicals and products. Acute systemic toxicity testing is used to properly classify and appropriately label materials with regard to their lethality potential in accordance with established regulatory requirements (49 CFR 173; 16 CFR 1500; 29 CFR 1910; 40 CFR 156). Non-lethal parameters may also be evaluated in ac...

It has become common practice in many laboratories in Europe to introduce the criterion "moribund" to reduce the suffering in fish acute lethality tests. Fish with severe sublethal symptoms might be declared moribund and are removed from the test as soon as this occurs (premature discontinuation of experiment). Moribund fish affect main study outcomes as the median lethal concentration (LC50) d...

The goal of the present study was to compare the different survival of Oxya chinensis exposed to chromium(VI) among allozyme genotypes to gain a better understanding of the relationship between the genetic variations and environmental disturbance. This study analyzed the occurrence of genotypes in O. chinensis population exposed to Cr(VI). O. chinensis samples were collected at Yuanping, Shanxi...

Using twenty chemicals commercially available or provided by NCI, we demonstrated the feasibility of using zebrafish embryos to study toxicity response by assessing Median Lethal Concentration (LC50), developmental teratogenicity, and specific liver and kidney toxicity. For the twenty compounds used to study LC50 and liver and kidney toxicity in zebrafish embryos, we found good correlation with...

  Glyphosate, N–(phosphonomethyl) glycine, has been widely used to control agricultural weeds in the north of Iran. However, it is also supposed to have adverse effects on natural sturgeon population. The present study was undertaken to evaluate the acute toxicity of glyphosate to three different sturgeon species (Huso huso, Acipenser stellatus, and A. persicus) under laboratory conditions. Fis...

  Glyphosate, N–(phosphonomethyl) glycine, has been widely used to control agricultural weeds in the north of Iran. However, it is also supposed to have adverse effects on natural sturgeon population. The present study was undertaken to evaluate the acute toxicity of glyphosate to three different sturgeon species (Huso huso, Acipenser stellatus, and A. persicus) under laboratory conditions. Fis...