Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Obesity has been identified as a serious health concern in domestic cats. Feline mammary cancer (FMC) is also concern, it highly prevalent and aggressive. Considering the connection between obesity breast cancer, worthwhile to investigate potential obesity–cancer relationship FMC. This review investigated association adipokines other obesity-associated molecules FMC, with aim of identifying gap...

Many studies have been performed to investigate the correlation of leptin (LEP) and leptin receptor (LEPR) polymorphisms with breast cancer (BC) risk, however the results are inconclusive. To obtain a more precise estimation, we conducted this meta-analysis. We searched PubMed, EMBASE, and Web of Science databases to identify qualified studies. Pooled odds ratios (ORs) with 95% confidence inter...

normal 0 false false false en-us x-none ar-sa background: metabolic syndrome (mets) is a serious public health problem. it is an important risk factor of cardiovascular disease in developed countries. adipose tissue considered as an organ that releases a variety of molecules referred to adipocytokines such as leptin.polymorphism of their related genes may play an important role in development o...

identification of genes affecting energy balance, milk yield and feed intake is an interesting area of researches in animal breeding. leptin gene polymorphism is associated with key economic affair. considering rich resources for animals, in our country, accomplishing a few assays to identify a gene that controls her traits with molecular genetics, and identifying the candidate genes in sheep b...

conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...

Leptin, an adipocyte-derived cytokine (adipokine), has plethora of physiological roles in the body, particularly onset puberty, reproduction and immune function animal. Leptin binds with leptin receptor (LEPR) activates different intracellular signaling pathways to activate downstream gene expression process execute its functions. The present mini-review focuses on our current understanding abo...

BACKGROUND The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychotic-induced weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the relationship between the leptin -2548G/A gene polymorphism and AIWG. METHODS Electronic databases were searched for eligible articles in English and ...