The effectiveness of the sulfones in the treatment of human leprosy is well known (9, 11). The antileprosy activity of streptomycin has been reported by several workers (6, 9, 11, 18). However, the action of these drugs on murine leprosy is stilI not established. Prom in has been reported to have an inhibitory action on rat leprosy (2, 5) and on mouse leprosy (8). Diasone has been considered ef...

OBJECTIVE To establish the categories of pre-service health training institutions in Uganda that still maintain leprosy in their curricula and how leprosy training is organised. MATERIALS AND METHODS A structured questionnaire was administered to the heads of 42 health training institutions including universities, paramedical and nurses' training schools. RESULTS Leprosy was included in the...

With wider use of multi drug therapy the milestone of leprosy elimination in India was achieved in December 2005. But as per statistics, around one million leprosy-affected patients with disability are living in India. The national leprosy elimination programme was started in 1983 and leprosy services were integrated into the general health services in 2004, with the aim that leprosy patients w...

BACKGROUND Leprosy is a public health problem and a neglected condition of morbidity and mortality in several countries of the world. We analysed time trends and spatiotemporal patterns of leprosy-related mortality in Brazil. METHODS We performed a nationwide population-based study using secondary mortality data. We included all deaths that occurred in Brazil between 2000 and 2011, in which l...

The epidemiology of leprosy is characterized by heterogeneity in susceptibility and clustering of disease within households. We aim to assess the extent to which different mechanisms for heterogeneity in leprosy susceptibility can explain household clustering as observed in a large study among contacts of leprosy patients.We used a microsimulation model, parameterizing it with data from over 20...

Leprosy is a neglected disease. We point up the need of recognizing the unusual clinical presentations of the disease in order to make early diagnosis and proper treatment possible, and break the transmission chain. The authors report a rare type of multibacillary leprosy: histoid leprosy and present images of numerous well-circumscribed indurated papules and nodules distributed throughout the ...

The pseudocholinesterase levels and the nature of the enzyme as shown by the dibucaine number (D.N.) were estimated in 720 controls and 420 lepromatous leprosy patients, and 301 tuberculoid leprosy patients. There was no statistical difference in the esterase levels between leprosy patients and normal controls. But the distribution of D.N. was significantly different in the leprosy patients co...

Leprosy control programs would benefit expressively from an easy method to estimate disease prevalence and to assess the effect of leprosy control measures on disease prevalence. Determination of the seroprevalence of antibodies to PGL-I through school children surveys might be a useful indicator of lep rosy prevalence at the distr ict level. To investigate whether seropositivity rates could be...

OBJECTIVE To examine the potential role of angiogenesis in leprosy. DESIGN Immunohistochemical analysis of leprosy lesions. SETTING Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. PATIENTS Thirty-two cutaneous lesions that repre...