La neurofibromatose de type 1 (NF1) ou maladie de Recklinghausen est une génodermatose autosomique dominante, elle touche de 1/3000 à 1/4000 personnes. La NF1 est caractérisée par une variabilité de son expression clinique qu'on peut retrouver au sein de la même famille. Des critères de diagnostic ont été établis en 1988. Le diagnostic de la NF1 est porté quand au moins deux des signes suivants...

BACKGROUND AND DESIGN The removal of benign, aesthetically important, pigmented lesions can be effectively treated with multiple modalities. Selective removal of the pigment by lasers is becoming increasingly popular. A three-center trial evaluated the effectiveness of the frequency-doubled Q-switched neodymium (Nd):YAG laser (532 nm, 2.0-mm spot size, 10 nanoseconds) in removing benign epiderm...

Themechanism for voriconazole-induced photosensitivity andphototoxicity remainsunknown.One current hypothesis includes a potentially phototoxic UV-B–absorbing N-oxide metabolite of voriconazole.4 Alternatively, inhibition of CYP450 with voriconazole therapy is thought to possibly increase serum retinol level, a known photosensitizer.5 Malignant skin conditions associated with chronic voriconazo...

Sir, Melanocytes are the skin cells most vulnerable to cold; they can be destroyed by temperatures of ± 4 to ± 73C (1). Lower tissue temperatures or repeated freeze ± thaw applications lead to skin necrosis (2). Selective destruction of melanocytic lesions by skin freezing can therefore be achieved without epithelial loss or skin necrosis if certain technical requirements are taken into account...

N oonan syndrome (MIM 163950), an autosomal dominant disorder with an estimated prevalence of 1/1000– 2500 at birth, is characterised by short stature, facial anomalies, pterygium colli, and congenital heart disease. 2 Although pulmonary valve stenosis with dysplastic leaflets, hypertrophic cardiomyopathy, and atrial septal defects (ASD) are the most common congenital heart defects in Noonan sy...

N oonan syndrome (MIM 163950), an autosomal dominant disorder with an estimated prevalence of 1/1000– 2500 at birth, is characterised by short stature, facial anomalies, pterygium colli, and congenital heart disease. 2 Although pulmonary valve stenosis with dysplastic leaflets, hypertrophic cardiomyopathy, and atrial septal defects (ASD) are the most common congenital heart defects in Noonan sy...