BACKGROUND Prozone phenomenon is seen with very high-titer antibodies in an immune serum. AIM The prozone effect on anti-D by a low-titer anti-Lea was investigated associated with neonatal jaundice. MATERIALS AND METHODS Standard methods were used in investigations. RESULTS The child was born at full-term developed mild jaundice. With weak direct antiglobulin test+, her indirect serum bil...

OBJECTIVE Diabetes confers a very high risk of lower-extremity amputation (LEA); however, few studies have assessed whether blood glucose control can reduce LEA risk among patients with diabetes, especially in practice settings where low-income patients predominate. RESEARCH DESIGN AND METHODS We performed a prospective cohort study (2000-2009) on patients with diabetes that included 19,808 A...

The entorhinal cortex (EC) serves a pivotal role in corticohippocampal interactions, but a complete description of its extrinsic connections has not been presented. Here, we have summarized the cortical, subcortical, and hippocampal connections of the lateral entorhinal area (LEA) and the medial entorhinal area (MEA) in the rat. We found that the targets and relative strengths of the entorhinal...

Late embryogenesis-abundant (LEA) proteins, accumulating to a high level during the late stages of seed development, may play a role as osmoprotectants. However, the functions and mechanisms of LEA proteins remained to be elucidated. Five major groups of LEA proteins have been described. In the present study, we report on the characterization of two members of soybean LEA IV proteins, basic GmP...

INTRODUCTION The risk of lower extremity amputations (LEAs) in diabetics is 20 times higher than in non-diabetics. Clinical practice guidelines recommend that all diabetics should receive an annual foot examination to identify high-risk foot conditions. Despite this recommendation, there is little evidence in the literature to show its effectiveness in preventing LEA. This study aims to evaluat...

The existing nonlinear local methods for dimensionality reduction yield impressive results in data embedding and manifold visualization. However, they also open up the problem of how to define a unified projection from new data to the embedded subspace constructed by the training samples. Thinking globally and fitting locally, we present a new linear embedding approach, called Locally Embedded ...

The endemic Australian genus Apteropilo Lea is revised and Pylusopsis Elston syn. n. found to be synonymous with the former. Apteropilo is redefined herein to include two previously described species (A. pictipes Lea (= Pylusopsis peckorum Kolibáč syn. n.) and A. chrysocome (Elston) comb. n.), and four new species (A. raldae sp. n., A. humerofuscus sp. n., A. clarinotus sp. n. and A. volans sp....

The carbohydrate antigen, sialyl Lex, is known to be a ligand for the cell adhesion molecule called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1), which is present on cytokine-activated human endothelial cells. Recently, we reported that another carbohydrate antigen, sialyl Lea, can also serve as a ligand for ELAM-1 (A. Takada, K. Ohmori, N. Takahashi, K. Tsuyuoka, K. Yago...

BACKGROUND We evaluated the risks of renal and cardiovascular complications, and mortality associated with lower extremity amputation (LEA) in patients with type 1 diabetes. METHODS We studied two cohorts of people with long standing type 1 diabetes: GENEDIAB (n = 456) and GENESIS (n = 611). Subsets of the cohorts (n = 260, n = 544) were followed for 9 and 5 years, respectively. Outcomes were...