The liberalisation of air transport created a new era in the sector. The entry of low-cost carriers triggered dynamism and consequently changed the behaviours of the demand and supply of air transport services. The volume of traffic at Portuguese airports increased from 17 million passengers in 2002 to more than 30 million in 2012, representing cumulative growth of 75%. The commitment to low-co...

In the last decade, Low Cost Carriers (LCCs) have increased greatly, both in terms of number of flights and the number of passengers. This growth has occurred mainly in secondary airports, where air-transport was previously generally private and/or military. The large increase in LCCs coupled with the consolidated urbanization around the secondary airports has caused a substantial problem with ...

Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contribution of miRNAs in the transformation of NFs into CAFs. We found that miR-1 and miR-206 were dow...

Although a few countries have banned flavored cigarettes (except menthol), flavors in most tobacco products remain unregulated across the globe. We conducted a systematic review of qualitative studies examining perceptions of and experiences with flavored non-menthol tobacco products. Of 20 studies on flavored tobacco products included in our qualitative systematic review, 10 examined hookah, s...

INTRODUCTION While some targeted agents should not be used in squamous cell carcinomas (SCCs), other agents might preferably target SCCs. In a previous microarray study, one of the top differentially expressed genes between adenocarcinomas (ACs) and SCCs is P63. It is a well-known marker of squamous differentiation, but surprisingly, its expression is not widely used for this purpose. Our goals...

It is now well established that characteristic properties of excitation-contraction (EC) coupling in cardiac myocytes, such as high gain and graded Ca(2+) release, arise from the interactions that occur between L-type Ca(2+) channels (LCCs) and nearby ryanodine-sensitive Ca(2+) release channels (RyRs) in localized microdomains. Descriptions of Ca(2+)-induced Ca(2+) release (CICR) that account f...

Excitation-contraction coupling (ECC) in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca(2+) transport. Voltage- and Ca(2+)-dependent L-type Ca(2+) channels (LCCs) allow for Ca(2+) entry into the myocyte, which then binds to nearby ryanodine receptors (RyRs) and triggers Ca(2+) release from the sarcoplasmic reticulum in a process known as Ca(2+)-i...

Micro fabricated accelerometer sensors have been developed to measure acceleration in a variety of applications, including automobile airbag crash sensors and seismic activity monitors. For this thesis a three-dimensional accelerometer sensor is used for measuring involuntary human hand motion (tremor). This human hand motion sensor uses three singleaxis accelerometers fabricated with a free sc...

land cover is one of basic data layers in geographic information system for physical planning and environmentalmonitoring. digital image classification is generally performed to produce land cover maps from remote sensing data,particularly for large areas. in the present study the multispectral image from irs liss-iii image along with ancillary datasuch as vegetation indices, principal componen...