نتایج جستجو برای: lats
تعداد نتایج: 350 فیلتر نتایج به سال:
The Drosophila melanogaster warts/lats tumour suppressor has two mammalian counterparts LATS1/Warts-1 and LATS2/Kpm. Here, we show that mammalian Lats orthologues exhibit distinct expression profiles according to germ cell layer origin. Lats2(-/-) embryos show overgrowth in restricted tissues of mesodermal lineage; however, lethality ultimately ensues on or before embryonic day 12.5 preceded by...
Despite rising incidence and mortality reported worldwide for CRC diagnosed in pts aged < 50 yrs, currently early onset metastatic (EOmCRC) are treated as their older counterparts. We aimed to investigate how this specific subgroup is real world. This an observational, retrospective, monocentric study aiming describe features, management prognosis of EOmCRC. Pts with EOmCRC at our Institution b...
In the United States today, adults live in a variety of nonmarital relationships and situations, ranging from committed partners who cohabit, to people cohabit with differing levels commitment,1 apart.2 An increasing number are single or families choice non-intimate partners, while some intimate multiple at same time.3 The COVID-19 pandemic has affected all these relationship forms differently....
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
PURPOSE To localize the sites of HSV1 latency in mice after a primary infection induced by injection into the lip and to assess their connection to the eye. METHODS The SC16 strain of HSV1, or a recombinant virus containing the HSV1 latency-associated transcript (LAT)-promoter driving expression of the LacZ reporter gene, were injected into the left upper lip. Tissues from animals killed at 6...
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