BACKGROUND In T4a laryngeal cancer with thyroid cartilage invasion, no optimal frontline treatment has yet been defined in controlled trials. METHODS We reviewed data from 89 patients with T4a laryngeal cancer featuring thyroid cartilage invasion who were treated initially with either total laryngectomy (n = 53) or a larynx-preservation strategy (n = 36). RESULTS The median progression-free...

Purpose/Objectives:Radiation therapy has become the primary treatment modality for cancer of the pharynx and larynx in many institutions in the United States. In patients with recurrent head and neck cancer that have failed radiation with or without chemotherapy, salvage surgery is the preferred treatment modality for curative intent. Salvage surgery in the post radiation setting is a significa...

Rhabdomyosarcoma of the larynx is an extremely rare disease. To date of the literature has been described only about 70 cases of rhabdomyosarcoma of the larynx, including the adult population — 39 cases. There is very little information about the clinical presentation and course of rhabdomyosarcoma of the larynx. The article presents a review of the literature and our own observations of the di...

Squamous cell carcinoma of the larynx continues to be the commonest head and neck cancer in many Western countries. The larynx plays a key role for many essential functions, including breathing, voice production, airway protection, and swallowing. The goals of laryngeal cancer treatment are thus to provide best possible oncologic control, while optimizing functional outcomes. In recent decades,...

OBJECTIVE To review the pathophysiology of early and late radiation-related tissue changes, methods to differentiate these changes from disease recurrence, and treatment of these changes in the irradiated larynx. DATA SOURCES Peer-reviewed publications. REVIEW METHODS PubMed database search. CONCLUSIONS/IMPLICATIONS FOR PRACTICE Early and late radiation-related changes in the larynx manif...

BACKGROUND Paraglottic space (PGS) is a connective tissue compartment of the larynx and is important in the extension of laryngeal cancer. It communicates with the preepiglottic space superiorly and with the extralaryngeal region inferiorly through the gap within the cricothyroid membrane. Transglottic cancer of the larynx, which spreads within PGS, is characterized by a high incidence of laryn...

AIMS To re-examine aerodigestive cancer risk in a cohort of autoworkers exposed to metal working fluids (MWF), using improved case definition and more recently diagnosed cases. METHODS The autoworker cohort included 31 100 hourly workers alive on 1 January 1985 who worked at three automobile plants in Michigan. A case-cohort design was carried out that included incident cases of cancers of th...

Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Supratracheal partial laryngectomy (STPL) has been described as a function-sparing surgical procedure for laryngeal cancer with sub-glottic extension. The aim of the present multi-institutional study was to focus on the indications and contraindi...