AIM OF THE STUDY Expression of EP2 protein, the prostaglandin E2 (PGE2) receptor, produced by tumour microenvironment inflammatory cells as well as tumour cells, may promote cellular proliferation and growth in an autocrine and paracrine fashion. The phenomenon involving these proteins is regulated by interleukin 1β (IL-1β). Many researchers indicate a connection of EP2 and IL-1β in various typ...

Background Cancer of the larynx occupies first frequency site cancer upper digestive tract and represents 42% malignant neoplasms aero-digestive tract. It is a potentially curable entity if it diagnosed in early stages. Objective Characterize clinical pathological features patients with laryngeal cancer, which can serve as guide for diagnostic suspicion primary secondary care. Method Descriptiv...

OBJECTIVES To examine the recent epidemiological evidence on cancer risk among workers in the rubber industry. METHODS Epidemiological studies published after the last detailed review by the International Agency for Research on Cancer (IARC) in 1982 were reviewed. 12 cohort studies in nine countries that examined distinct populations of workers in the rubber industry, seven industry based nes...

Thirty laryngeal carcinomas from patients without pre-existing laryngeal papillomatosis were examined by PCR for the presence of HPV DNA. The utmost care was taken during sectioning of the tissue blocks and DNA-extraction in order to avoid false positive results. Three pairs of consensus primers were used: MY9/MY11, GP51/GP61 and CPI/CPII. HPV was detected in 1/30 carcinomas. The HPV type prese...

Liposarcomas of the larynx are extremely rare tumors, with only 37 cases reported in the English or French literature to date. The first two cases of laryngeal liposarcomas were reported respectively by Kapur and Dockerty in 1968 [1, 2]. Liposarcoma of the larynx is at high risk of local recurrence and seldom has metastatic potential. Prognosis for this tumor is better than that of non laryngea...

spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. spindle cell neoplasms can affect the oral cavity. in the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. this article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology.  ...

 Background: Focal laryngeal candidiasis is not reported widely and is very infrequently recognized clinically. This disease is rare and may occur after pulmonary, pharyngeal and esophageal candidiasis or as part of disseminated disease. It is also secondary to inhaled steroid therapy which is usually mild and has been reported in 10-15 percent of patients taking these medications.  Case Pr...

introduction: laryngeal dysfunction may be divided into three categories; organic, neurologic and functional disorders. dysphonia and hoarseness are the most common symptoms and, in some cases, the only signs of laryngeal dysfunction. in differential diagnosis of any type of chronic hoarseness, a neoplastic process must be considered and, thus continuous light video laryngoscopy can provide imp...