XP is a code-oriented, light-weight software engineering methodology, suited merely for small-sized teams who develop software that relies on vague or rapidly changing requirements. Being very code-oriented, the discipline of systems engineering knows it as approach of incremental system change. In this contribution, we discuss the enhanced version of a concept on how to extend XP on large scal...

Data migration projects might sound exotic. They are not. Instead, they are common in all medium and large enterprises, e.g., when replacing applications with new (standard) software or when consolidating the IT landscape in the aftermath of mergers and acquisitions activities. Generalpurpose methodologies such as Scrum focus on managing projects. However, they do not discuss (data-migration) d...

Good accessibility of publicly funded research data is essential to secure an open scientific system and eventually becomes mandatory [Wellcome Trust will Penalise Scientists Who Don't Embrace Open Access. The Guardian 2012]. By the use of high-throughput methods in many research areas from physics to systems biology, large data collections are increasingly important as raw material for researc...

Many project managers of a large scale project shortened delivery period of his or her projects unwillingly by the request of clients. However, some of them believe there is no difference between a large scale project and a small scale project in shortening the delivery period and accept shortening finally. This is because they are not informed theoretically of what impact can be made by shorte...

UNLABELLED The Web-Based GeneChip Analysis System (WGAS) is developed to overcome limitations in analysis setup efficiency, data and procedure sharing, as well as security issues in existing commercial and public domain solutions. It also incorporates unique functions and resources for more accurate and flexible GeneChip analysis. AVAILABILITY WGAS is freely available at: http://arrayanalysis...

A problem in many sequencing projects is the final closure of gaps left in the clone libraries, which serve as templates for sequencing, because of uncloned or unclonable genomic areas. By use of the Xylella fastidiosa genome as a test system, we present here an approach to generate, in a directed manner, sequence information from those gaps. We suggest using the complete clone library as a com...

Many modern new product development (NPD) embedded software projects are required to be run under turbulent conditions. Both the business and the technological environments are often volatile. Uncertainty is then an inherent part of the project management. In such cases, traditional detailed up-front planning with supporting risk management is often inadequate, and more adaptive project managem...

Elaine Mardis and Marc Ladanyi discuss how large-scale genomics has driven advances in cancer translational medicine, with a focus on publications in this month's Special Issue.

Cost estimation for large projects can be difficult because of many complex factors and uncertainties involved. It is often the case that only very rough guesses of actual costs may be provided. In this paper, we will examine the various types of uncertainties in the cost estimation problem of the Myrrha project. We will then use a few examples originated from the conceptual phase of the projec...

Like most bioethical discussion, examination of human biobanks has been largely framed in terms of research subjects’ rights, principally informed consent, with some gestures toward public benefits. However, informed consent is for the competent, rights-bearing individual: focussing on the individual, it thus neglects social, economic and even political matters; focussing on the competent right...