The majority of patients with end-stage renal disease have hyperphosphataemia, which is associated with significant morbidity and mortality. Lanthanum carbonate has been introduced as a new treatment modality to lower serum phosphorus. But there has been ongoing concern about lanthanum accumulation in tissues, especially in liver. We describe the case of a woman with pre-existing liver disease,...

In this report intercellular material in developing cartilage and between reaggregating cartilage cells has been examined with lanthanum staining (3, 7, 13, 16) . The proteinpolysaccharides of cartilage have been extensively studied by biochemical methods (2, 8-10, 18-21), and proteinpolysaccharide extracted from cartilage has been shown to precipitate with lanthanum (2) . The lanthanum-stainin...

Basal vascular endothelial permeability is normally kept low in part by the restrictiveness of interendothelial junctions (IEJs). We investigated the possible role of nitric oxide (NO) in controlling IEJ integrity and thereby regulating basal vascular permeability. We determined the permeability of continuous endothelia in multiple murine vascular beds, including lung vasculature, of wild-type ...

The effects of major mineral salts, L-glutamine, myo-inositol and carbon source on shoot bud proliferation of date palm (Phoenix dactylifera L.) cv. Mejhoul were evaluated. Different concentrations of ammonium nitrate (NH4NO3; 550, 825 or 1650 mg/L), potassium nitrate (KNO3; 633.3, 950 or 1900 mg/L), calcium chloride dehydrate (CaCl2·2H2O; 147, 220 or 440 mg/L), potassium dihydrogen phosphate (...

Precursors of lanthanum oxide and of (3La2O3, 5Ga2O3, SiO2) system were first elaborated then thermally decomposed into polycrystalline lanthanum oxide and langasite La3Ga5SiO14. The as prepared lanthanum oxide powder was then hydrated and carbonated to give hydroxicarbonates: thermal decomposition of these complex system La2O3-X(OH)y(CO3)z was studied by Fourier Transform infrared spectroscopy...

BACKGROUND To prospectively evaluate an elastin-specific MR contrast agent (ESMA) for in vivo targeting of elastic fibers in myocardial infarction (MI) and postinfarction scar remodeling. METHODS AND RESULTS MI was induced in C57BL/6J mice (n=40) by permanent ligation of the left anterior descending coronary artery. MRI was performed at 7 and 21 days after MI. The merits of gadolinium-based E...

OBJECTIVES We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood. BACKGROUND Activation of the membrane glycoprotein (GP) IIb/IIIa--mediated in part through the P2Y1 and P2Y12 adenosine 5'-diphosphate (ADP) receptors--is necessary for platelet aggregation. Platelets in growing thrombi exhibit cyclic calcium si...

The effects of lanthanum on the resting membrane potential, action potential, membrane resistance, twitch tension, and potassium contracture were investigated and the localization of the drug was studied electron microscopically in isolated frog ventricular muscle. Lanthanum in concentration of 0.2 to 5 mM decreased the resting potential by about 5-8 mV, which was accompanied by an increase in ...

BACKGROUND Control of serum phosphate over the long term is essential in patients with end-stage renal disease. Six-month and 2-year extensions to a 6-month study evaluated the long-term safety, tolerability and efficacy of the new phosphate binder lanthanum carbonate. METHODS Patients who participated in a 6-month, randomized trial comparing lanthanum carbonate with calcium carbonate were el...