BACKGROUND Atherosclerosis and vascular calcification (VC) progression in chronic kidney disease is favored by disturbances of mineral metabolism. We compared the effect of phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC and bone structure and function in mice with chronic renal failure (CRF). METHODS Apolipoprotein E-deficient (apoE(-/-)) mice were randomi...

Because of its diverse physical and chemical properties, lanthanum has been used in various industrial and medical fields. However, until recently, its effects at the cellular and molecular level had hardly been investigated. Using primary cortical networks grown on microelectrode array neurochips, we investigated the acute functional neurotoxicity of lanthanum(III) chloride (LaCl(3)). Lanthanu...

Micro- and nanocrystalline lanthanum-samarium ferrites La1-x Sm x FeO3 with orthorhombic perovskite structure were obtained by using both solid state reactions (x = 0.2, 0.4, 0.6 and 0.8) and sol-gel synthesis (x = 0.5) techniques. Obtained structural parameters of both series of La1-x Sm x FeO3 are in excellent agreement with the "pure" LaFeO3 and SmFeO3 compounds, thus proving formation of co...

Calciphylaxis is a rare and debilitating vasculopathy predominantly seen in patients with renal failure. The proposed mechanism of injury is active vascular calcification with associated elevated parathyroid hormone, hypercalcemia, or hyperphosphatemia. With improved pharmacologic agents including non-calcium containing phosphate binders, vitamin D analogues, calcimimetics, and bisphosphonates,...

Europium and terbium-doped lanthanum hydroxycarbonate and lanthanum oxycarbonate nanoparticles were fabricated under two different reaction conditions using lanthanide acetate and urea as the starting materials. The photoluminescence properties of these hydroxycarbonate and oxycarbonate particles, and of their colloidal suspensions in water, were studied. The Eu(3+) (5)D(0)→(7)F(J) and Tb(3+) (...

BACKGROUND Calcium-based and non-calcium-based phosphate binders have similar efficacy in the treatment of hyperphosphatemia; however, calcium-based binders may be associated with hypercalcemia, vascular calcification, and adynamic bone disease. SCOPE A post hoc analysis was carried out of data from a 16-week, Phase IV study of patients with end-stage renal disease (ESRD) who switched to lant...

The anatase form of TiO2 has been examined for the sensing of CO and CH4 at temperatures of 873 K. Though, there were differences in the sensitivity of the anatase sensor towards CO and CH4, both gases showed considerable resistance changes. However, in the presence of lanthanum oxide and copper oxide (labeled as ALC sensor), the sensor showed minimal response towards CH4, while still exhibitin...

Elevated serum phosphate levels as a consequence of chronic kidney disease (CKD) contribute to the increased cardiovascular risk observed in dialysis patients. Protein restriction and dialysis fail to adequately prevent hyperphosphatemia, and in general treatment with oral phosphate binding agents is necessary in patients with advanced CKD. Phosphate plays a pivotal role in the development of v...