This study aims to determine changes in the morphology, number, and diameter of Langerhans Islets cells White Sprague Dawley rats with diabetes mellitus after treatment ethyl acetate fraction synom lime honey mixture. is an experimental which divided into 5 groups, control group (negative positive control), induced by alloxan were then given mixed sinom, lime, a dose 50; 100; 150; 200 mg/kg. Th...

BACKGROUND Leptin and adiponectin are the two key metabolic hormones secreted from adipocytes to control food intake and energy expenditure. The action of both hormones in regulation of Gonadotropin Releasing Hormone (GnRH) secretion from the hypothalamus is mediated through Kisspeptins. Kisspeptins are products of KiSS-1 gene. Leptin and adiponectin are modulators of KiSS-1 expression in the h...

objectives: this study investigates the effects of hydro-alcoholic extract of prangos ferulacea (l.) lindle (p.f) on rats' pancreas structure changes and diabetic treatment after streptozotocin injection. materials and methods: in this research forty male wistar rats with body weights of 100±20 gram, were randomly divided into 5 groups with 8 rats per each group. diabetes was induced in ra...

OBJECTIVE To evaluate the antidiabetic effect of curcumin and its potential in amelioration of pancreatic islets against damage under diabetic condition. MATERIAL AND METHOD Diabetic mice were induced by injection of STZ (60 mg/kg body weight). Male mice were divided into 3 groups: group I was normal mice, group II was diabetic mice and group III diabetic mice were treated with curcumin (200 ...

The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of i...

Changes in the intracellular concentrations of Ca2 + and cyclic AMP (for reviews see Hedeskov, 1980; Wollheim & Sharp, 1981), as well as alterations in phosphatidylinositol turnover (Freinkel et al., 1975; Clements & Rhoten, 1976; Clements et al., 1977), have been proposed to be key events in stimulus-secretion coupling in the pancreatic fl-cell. The principal mediator of the action of cyclic A...

OBJECTIVES In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated. MATERIALS AND METHODS Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise str...

The present studies were designed to determine effects of a microgravity model system upon lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) activity and indexes of insulin and fuel homeostasis of pancreatic islets of Langerhans. Islets (1,726 +/- 117, 150 islet equivalent units) from Wistar-Furth rats were treated as 1) high aspect ratio vessel (HARV) cell culture, 2)...

AIM To identify the types of endocrine cells in the pancreas of the Sunda porcupine (Hystrix javanica) and its immunolocalization. MATERIALS AND METHODS Five adult H. javanica were used without sexual distinction. The presences of endocrine cells (glucagon, insulin, somatostatin, and pancreatic polypeptide [PP]) in pancreatic tissues were detected using the avidin-biotin-peroxidase complex me...

A preliminary study revealed pancreatic hyperplasia to be present in 29 per cent of 100 consecutive necropsies. Malignant neoplasms coexisted with hyperplasia of islets in 14 (48.3 per cent) of the 29 cases. On the basis of the results of this study, the islets of Langerhans in microscopic sections of pancreas from 20 cases of accidental death (normal controls), 10 cases of extrapancreatic lymp...