Cancer is a disease regulated by the underlying gene networks. The emergence of normal and cancer states as well as the transformation between them can be thought of as a result of the gene network interactions and associated changes. We developed a global potential landscape and path framework to quantify cancer and associated processes. We constructed a cancer gene regulatory network based on...

DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the mechanisms underlying cell growth, differentiation and transformation in eukaryotes. Global changes in the epigenetic landscape are considered to be a hallmark of cancer. The initiation and progression of cancer are mediated through epigenetic modifications along with genetic alterations. Aberrant...

The number of business applications operated by enterprises to provide support for the business has increased over the last years. With increasing number of applications and connections between them, also the overall complexity of the application landscape has grown. A main task in managing an application landscape is maintaining quality levels. This article contributes a set of metrics for mea...

fragmentation is one of the major spatial processes leading to change in a landscape, which is described as transformation of a specific habitat or land cover to smaller patches with less connectivity and viability. construction of roads is one of the main causes of fragmentation in natural areas and habitats. presence of roads in ecologically sensitive and protected areas, leads to destruction...

BACKGROUND People influence their environments through the manipulation of landscapes and species. Human influence on the landscape may lead to the development of differentiated landscape units that originate from past use and may be related to the presence of certain species. This study investigated the presence of the palm Euterpe edulis and its current and past importance in landscape units ...

A new two dimensional (2-D) object recognition method is proposed to differentiate similar objects, detect defective objects, and recognize printed characters. First, a 2-D image is transformed to a weighted shape matrix to secure invariance in translation, scaling, rotation, and split into four dyadic subimages. Wavelet transformation is applied to each subimage in order to further explore its...