RATIONALE Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes. PATIENT CONCERNS A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, p...

Latent autoimmune diabetes in adults (LADA) is a slowly progressing form of immune-mediated diabetes often misdiagnosed as type 2 diabetes because of its typical clinical presentation, i.e., an adult without weight loss or ketoacidosis not initially requiring insulin (1). Prior to insulin dependence, pharmacological options for reducing hyperglycemia comprise the oral glucose-lowering drugs use...

In this issue of Diabetes, Cervin et al. (1) investigated whether patients with latent autoimmune diabetes in adults (LADA) (defined as age at diabetes onset 35 years, GADA positive), analyzing known risk alleles for type 1 and type 2 diabetes, share genetic polymorphisms with type 1 diabetes (age at onset 35 years) and/or type 2 diabetes (age at onset 35 years, GADA negative). In their LADA pa...

Esse estudo consiste em diagnosticar e tratar de maneira adequada o diabetes tipo LADA através da anamnese, exame físico controle glicêmico, para que os pacientes sejam identificados precoce manejados forma correta, visto que, é uma comorbidade a qual pode se manifestar diversas formas, confundindo raciocínio clínico. Palavras-chave: LADA; autoanticorpos; diagnóstico clínico; hiperglicemia; doe...

63 Am J Health-Syst Pharm—Vol 64 Jan 1, 2007 PAMELA LADA, PHARM.D., is Clinical Emergency Medicine Specialist, Department of Emergency Medicine, Boston Medical Center, Boston, MA. GEORGE DELGADO, JR., PHARM.D., is Coordinator, Emergency Pharmacy Services, and Clinical Emergency Medicine Specialist, Department of Emergency Medicine, Detroit Receiving Hospital and University Health Center, Detroi...

OBJECTIVE This study investigated the relationship between GAD autoantibody (GADA) titers and changing of β-cell function in patients with latent autoimmune diabetes in adults (LADA). RESEARCH DESIGN AND METHODS This 3-year prospective study enrolled 95 subjects from 15 Chinese cities including 25 high-titer (GADA ≥180 units/mL) LADA patients, 42 low-titer (GADA <180 units/mL) LADA patients, ...

BACKGROUND Latent autoimmune diabetes in adults [LADA] is a type 1 diabetes that is slowly developing. This means many people are treated as having type 2 diabetes at diagnosis as they are adults who are not immediately insulin dependent. LADA can be distinguished from type 2 diabetes by antibody tests. Patients who are antibody positive have an autoimmune reaction which is similar to that of t...

Background and Aims: The prevalence of latent autoimmune diabetes in adults (LADA) among diabetic patients is less recognized and underdiagnosed. The aim of this study was to determine the prevalence of LADA in type 2 diabetic patients and to compare the characteristics of these two groups in Torbat-e Heydarieh, Iran. Materials and Methods: Totally, 198 male and 277 female patients diagnosed ...

In these notes we give a brief introduction to Kolmogorov complexity. The notes are based on the two talks given at KAM Spring School, Borová Lada, 2006.

The etiopathological relationship between latent autoimmune diabetes in adults (LADA) and classical type 1 (insulin dependent) diabetes remains unclear. Variation at the insulin gene variable number of tandem repeats (VNTR) minisatellite influences susceptibility to type 1 diabetes, but studies in LADA have been small and inconsistent. We examined the role of insulin gene variation (using flank...