A bolus injection of [14C]lactate was used to measure lactate turnover rates at rest and during recovery from exhaustive exercise in coho salmon (Oncorhynchus kisutch) and starry flounder (Platichthys stellatus). At rest, lactate turnover rate in salmon was almost double that in flounder (1.33 versus 0.76 mumol min-1 kg-1), which reflected the higher blood lactate level in salmon (1.00 versus 0...

Abstract Lactate clearance is affected by hepatic function. However, it unclear whether the association between dysfunction and lactate can act as a prognostic marker of clinical outcomes in patients with septic shock. We aimed to evaluate mortality two cohorts shock patient who had based on their total serum bilirubin levels (TBIL). at 24 h after onset was analyzed using cohorts, sub-categoriz...

OBJECTIVES Sepsis treatment guidelines recommend macrocirculatory hemodynamic optimization; however, microcirculatory dysfunction is integral to sepsis pathogenesis. We aimed to test the hypothesis that following macrocirculatory optimization, inhaled nitric oxide would improve microcirculation in patients with sepsis and that improved microcirculation would improve lactate clearance and multip...

Introduction Serial lactate measurements provide a valuable tool to risk-stratify patients, determine the presence of ongoing tissue hypoperfusion, and potentially evaluate efficacy of therapeutic interventions. Prior studies have shown lactate clearance to be a valuable predictor of patient outcomes, however some have defined adequate change in lactate by a decrease from baseline by 10% wherea...

Blood lactate levels are frequently measured in critically ill patients. Whilst these measurements are known to be accurate, for the correct interpretation of hyperlactataemia, it is essential to have sufficient understanding of anaerobic and aerobic mechanisms of production and clearance. The consistency of the prognostic value emphasizes the place of lactate measurement in the risk-stratifica...

Prognostication of survival after out-of-hospital cardiac arrest (OHCA) remains challenging with current guidelines recommending the prognostication no earlier than 72 h return spontaneous circulation (ROSC). Prognostic factors that could be used ROSC, like lactate clearance, are still being studied. This paper aims to investigate prognostic strength early clearance for OHCA. retrospective obse...