Reptiles habitually ingest large meals at infrequent intervals, leading to changes in acid-base status as the net secretion of acid to the stomach causes a metabolic alkalosis (the alkaline tide). In chronically cannulated and undisturbed amphibians and reptiles, the pH changes in arterial blood are, nevertheless, reduced by a concomitant respiratory acidosis (increased P(CO2) caused by a relat...

lives in streams or pools that are liable to dry up or become stagnant, and these animals are known to leave water voluntarily to forage or to invade neighbouring habitats (Huxley, 1896; Taylor and Wheatly, 1980). When placed in air, the gills collapse and the crayfish suffer continuously from systemic hypoxia and hypercapnia. Associated with an initial virtual anoxia and a switch to anaerobic ...

Colonic bicarbonate (HCO3(-)) secretion is a well-established physiological process that is closely linked to overall fluid and electrolyte movement in the mammalian colon. These present studies show that extracellular calcium-sensing receptor (CaSR), a fundamental mechanism for sensing and regulating ionic and nutrient compositions of extracellular milieu in the small and large intestine, regu...

RATIONALE Recently tenofovir disoproxil fumarate (TDF) has been widely used as a first-line therapy for chronic hepatitis B (CHB) infection. Although TDF demonstrates successful viral suppression, the possibility of renal failure and lactic acidosis has been proposed with TDF administration, especially in human immunodeficiency virus co-infected patients. However, TDF induced lactic acidosis ha...

Bonanno, Joseph A., Yi Guan, Sergey Jelamskii, and Xiao Jun Kang. Apical and basolateral CO2-HCO3 2 permeability in cultured bovine corneal endothelial cells. Am. J. Physiol. 277 (Cell Physiol. 46): C545–C553, 1999.—Corneal endothelial function is dependent on HCO3 2 transport. However, the relative HCO3 2 permeabilities of the apical and basolateral membranes are unknown. Using changes in intr...

Six males performed cycle ergometer exercise on two occasions in random order. Each exercise was preceded by a 2-h period in which matched capsules were administered orally, containing either starch (C) or NaHCO3 (E) in a dose of a 0.2 g.kg-1 body wt; pre-exercise blood pH and [HCO3-] were 7.34 +/- 0.01 and 23.7 +/- 0.5 mM (mean +/- S.E.) for the C study, and 7.41 +/- 0.01 and 28.6 +/- 1.3 mM f...

In the rabbit small intestine, there are three functionally different brush-border membrane (BBM) anion/HCO3- exchangers: 1) Cl/HCO3- exchange on the BBM of villus cells responsible for coupled NaCl absorption; 2) Cl/HCO3- exchange on the BBM of crypt cells possibly involved in HCO3- secretion; and 3) short-chain fatty acid (SCFA)/HCO3- exchange on the BBM of villus cells, which facilitates SCF...

HCO3- absorption and its association with Na+ absorption has been studied in the rat jejunum in vivo, using a single-pass perfusion technique. The method of disequilibrium pH, the only valid way of demonstrating jejunal H+ secretion, was used to distinguish between an HCO3- pump and H+ secretion as the mechanism of HCO3- absorption. HCO3- stimulated Na+ absorption; Na+ deletion inhibited HCO3 a...

Although endogenous CO2 hydration and serosal HCO3- are both known to contribute to the high rates of intestinal HCO3- secretion important to marine fish osmoregulation, the basolateral step by which transepithelial HCO3- secretion is accomplished has received little attention. Isolated intestine HCO3- secretion rates, transepithelial potential (TEP) and conductance were found to be dependent o...

Objective: Umbilical cord clamping time is a situation that should be planned before delivery. It recommended the umbilical clamped for at least 30–60 seconds after birth in healthy preterm and term newborns. There are few studies investigating effect of on blood gas. If 30 birth, it considered early clamping, if seconds, late clamping. In this study, we aimed to compare or with acid-base param...