Data to inform prescribing of antihypertensive treatments for chronic hypertension in pregnancy are sparse and subsequently no consensus on the optimal agent(s) exists. The prevalence of chronic hypertension in pregnancy is estimated at 3%, but this figure is set to increase with rising maternal age and the global obesity epidemic. Given that chronic hypertension is associated with significantl...

Antihypertensive agents have been associated with adverse reactions that, if unrecognized by health practitioners, may have devastating consequences. The pattern of hepatotoxicity observed during therapy with the vasodilator hydralazine is highly variable, often making its diagnosis difficult. Serious hepatic injury induced by the alpha- and beta-adrenergic receptor antagonist labetalol has onl...

Abstract Background Drug-induced liver damage with clinical symptoms has been related to labetalol in a number of instances. In addition having wide range anti-inflammatory and antioxidant qualities, ginger also includes biotrace that are crucial the fight against disease skeletal deformity. this study, we hypothesized prenatal supplementation (200 mg/kg) attenuates malformation hepatotoxicity ...

background rhinoplasty is one of the most common surgeries of the plastic surgery and as well as ear, throat and nose. intra-operative bleeding during surgery is one of the most important factors that may impair the surgeon’s job. providing a clean blood-free surgical filed makes the operation faster, easier and with a better quality. one way to achieve this goal is to induce hypotension. this ...

Noradrenaline contributes to olfactory-guided behaviors but its role in olfactory learning during adulthood is poorly documented. We investigated its implication in olfactory associative and perceptual learning using local infusion of mixed α1-β adrenergic receptor antagonist (labetalol) in the adult mouse olfactory bulb. We reported that associative learning, as opposed to perceptual learning,...

To the Editor: Although the Bier block has been used as a treatment for sympathetically-maintained pain (SMP) for many years, the selection of agents remains controversial. Different drug classes have been used, including alpha-adrenergic blockers (guanethidine, reserpine, bretylium), alpha-2 agonists (clonidine), nonsteroidal antiinflammatory agents (ketorolac, tenoxicam), local anesthetics (l...

INTRODUCTION Controlled release oral dosage forms are in the focus of interest for several reasons. Customer compliance with the trend to simplicity and more comfort of use, the prolonged drug release with more reliable blood levels than those obtained with conventional dosage forms and life-cycle management of existing API’s directed the pharmaceutical development towards sustained release for...