I. Urinary excretion of tryptophan metabolites of the kynurenine pathway before and after a loading dose of 2 g of L-tryptophan (both before and during supplementation with vitamin B6) was studied in normal young male subjects and in elderly male subjects with prostatic diseases. 2. The increase in urinary excretion of tryptophan metabolites in the normal male subjects after a loading dose of 2...

The implementation of a novel cell recycling technology based on a special disk centrifuge during microbial fermentation process can continuously separate the product and harmful intermediates, while maintaining the cell viability owing to the installed cooling system. Acetate accumulation is an often encountered problem in L-tryptophan fermentation by Escherichia coli. To extend our previous s...

BACKGROUND L-tryptophan is used widespread in the pharmaceutical industry. The majority of L-Trp production depends on microbial processes that produce L-tryptophan from indole and L-serine. These processes are very costly due to the costs of precursors, especially L-serine. Use of inexpensive substitutions as the L-serine source of L-tryptophan production enables us to reach a cost-effective p...

An enzyme which catalyzes the conversion of L-tryptophan to indole-3-acetamide has been isolated from cells of Pseudomonas savastanoi and purified 89-fold. The enzyme catalyzes a reaction in which 1 mole of L-tryptophan and 1 mole of 02 are consumed and 1 mole of indole-3-acetamide and 1 mole of CO2 are produced. The enzyme has a pH optimum between 7.2 and 9.2. It is specific for the L isomer o...

An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan's role in synthesis of brain serotonin, details are provided on the ...