نتایج جستجو برای: ku
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Telomere length is tightly regulated in cells that express telomerase. The Saccharomyces cerevisiae Ku heterodimer, a DNA end-binding complex, positively regulates telomere length in a telomerase-dependent manner. Ku associates with the telomerase RNA subunit TLC1, and this association is required for TLC1 nuclear retention. Ku-TLC1 interaction also impacts the cell-cycle-regulated association ...
KU-812-F is a subclone of KU-812, which has cytological features similar to the parent clone, and which carries the Philadelphia chromosome. We studied the effects of various chemical agents and serum-free culture (SF-C) condition on its differentiation. The KU-812-F subclone differentiated into macrophage-like cells with phorbol myristate acetate (PMA), but not with other agents. Unexpectedly,...
Department of Public Health, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601 [S. T., K. K., J. C., T. F., T. N., H. I.]; Nagoya City School of Nutrition, Mizuho-ku, Nagoya 467-0011 [N. I.]; Nagoya-Bunri College, Nishi-ku, Nagoya 451-0077 [Y. T., C. G.]; and Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-860...
The aim of this note is to rederive this result with the aid of stable operations related to the Hecke operators which were originally constructed in [1,2] and discussed further in [5,6]. Hitherto, these operations appear to have lacked serious topological applications. Our approach is modelled on one previously used in proving the analogous result in K-theory, Ext KU∗KU (KU∗,KU∗) ∼= Z/m(|n|) i...
and other STDs. Men in their 20s are more likely to be sexually active and are less likely to use condoms than teenagers.4 Their high-risk sexual behavior also leads to increased risk for disease: Half of all new HIV infections in the United States are among people younger than 25,5 and young men aged 20–24 have the highest rate of gonorrhea infection among all male age-groups.6 In contrast to ...
Methods: Data on the sexual behavior, sexual attitudes, educational experiences and demographics of 2,087 never-married metropolitan males aged 17–19 from the 1979 National Survey of Young Men and the 1988 and 1995 waves of the National Survey of Adolescent Males were analyzed through multivariate methods to examine factors that predict sexual behavior as well as those that predict sexual attit...
INTRODUCTION An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based on their autoantibody profile and clinical signs/symptoms and to establish possible correlations between antibodies against Ku p70 and Ku p80 with autoimmune diseases. METHODS Sera of anti-Ku-posi...
The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae
In Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a ring-shaped protein heterodimer best known for its function in DNA repair. Ku binding to yeast telomerase RNA promotes telomere lengthening and telomerase recruitment to telomeres, but how this is achieved remains unknown. Using telomere-length analysis and chromatin immunoprecipitation, we show that Sir4 - ...
The binding of the Ku protein to DNA was investigated using the atomic force microscope@Ku was found to bind predominantly to the ends of double-stranded DNA. Experiments with plasmid DNA revealed that Ku does not bind to circular plasmids but does bind to plasmids that have been linearized by treatment with ionizing radiation. The binding ofKu to poly(dG-dC)poly(dG-dC) polynucleotides and to a...
Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan 1Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan 2Division of Research and Development, MedTech Heart Inc., 3-24-8 Asakusabashi, Taito-ku, Tokyo 111-0053, Japan 3School o...
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