The Fungal Secretome KnowledgeBase (FunSecKB) provides a resource of secreted fungal proteins, i.e. secretomes, identified from all available fungal protein data in the NCBI RefSeq database. The secreted proteins were identified using a well evaluated computational protocol which includes SignalP, WolfPsort and Phobius for signal peptide or subcellular location prediction, TMHMM for identifying...

The UniProt knowledgebase is a large resource of protein sequences and associated detailed annotation. The database contains over 60 million sequences, of which over half a million sequences have been curated by experts who critically review experimental and predicted data for each protein. The remainder are automatically annotated based on rule systems that rely on the expert curated knowledge...

One of the current issues in the bioinformatics domain is to identify genomic variations underlying the complex diseases. There are millions of genetic variations as well as environmental factors that may cause human diseases. Semantic web interlinks diverse data that may reveal many hidden relations and can be utilized for personalized medicine. This requires discovering relationships between ...

Three-dimensional domain swapping is a unique protein structural phenomenon where two or more protein chains in a protein oligomer share a common structural segment between individual chains. This phenomenon is observed in an array of protein structures in oligomeric conformation. Protein structures in swapped conformations perform diverse functional roles and are also associated with depositio...

A substantial knowledgebase is an important part of many A.I. applications as well as (arguably) in any system that is claimed to implement broad-range intelligence. Although this has been an accepted view in our field since very long, little progress has been made towards the establishment of large and sharable knowledgebases. Both basic research projects and applications projects have found i...