Head and neck cancer, including oral cancer, is the sixth most common cancer in humans worldwide. More than 90% of oral cancers are of squamous cell carcinoma type. Recent studies have shown a strong relationship between human papillomavirus (HPV) infection and head and neck cancer, especially oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). Moreover, the i...

lichenoid reactions represent a family of lesions with different etiologic factors and a common clinical and histologic appearance. lichen planus is included with lichenoid reactions and is a relatively common chronic mucocutaneous disorder. the most important complication of lichenoid reactions is the possibility of malignant transformation. that is why it has been considered a precancerous co...

background: there is a variation in trends of oral cancers all over the world. many studies have reported evidence of increasing incidence in oral cancers during recent years. the purpose of this study was to investigate time trends and changes in demographic distribution of oral cancers incidence in isfahan during 1991-2010. materials and methods: in this retrospective analytic study, we colle...

Oral cancer is a growing problem globally and in some countries including India, Pakistan, Sri Lanka, and Taiwan is right at the top of the ladder. More than 95% of all oral malignancies are oral squamous cell carcinoma. Tobacco, alcohol, and betel quid (BQ) use have been recognized as risk factors of oral cancer. Cigarette smoking and alcohol drinking are the major risk factors in Western coun...

background: tumor markers are substances, which quantitatively changes in serum, during the tumor development, one such tumor marker is serum β2-microglobulin (β2-m). the aim of this study was to establish the role of β2-m as a biochemical parameter for diagnosis and prognosis of oral carcinoma by estimation of serum β2-m levels in potentially malignant lesions, conditions, and oral squamous ce...

background and objective: oral cancer accounts for less than 3% of all cancers. despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. several studies have been performed to assess factors influencing lymph node metastasis and prognosis. the aim of this study was to evaluate some clinical and pathological factors influencing lymph nod...

Of all Cancers, Oral cancer is one of the most typical cancers in world. has delayed clinical detection, poor prognosis, without specific biomarkers, and expensive therapeutic methods. This study aims to explain basic aspects oral focuses on squamous cell carcinoma cavity. The duration detection depends amount tobacco usage individual. In this study, we have presented stochastic models for onse...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

abstract background: esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. this may be due to increasing rates of barrett’s esophagus, gastroesophageal reflux, smoking and obesity. this study was performed from 1991 to 2005 in order to evaluate variou...

cancer of the oral cavity accounts for approximately 3% of all malignancies diagnosed annually in 270,000 patients worldwide. oral cancer is the 12th most common cancer in women and the 6th in men. many oral squamous cell carcinomas develop from potentially malignant disorders (pmds). lack of awareness about the signs and symptoms of oral pmds in the general population and even healthcare provi...