background: due to difficulty of obtaining a 24h urine (especially in children), a random urine calcium sample is recommended to detect of hypercalciuria. however, recent studies have shown that the urinary calcium/creatinine ratio varies with age and geographic areas. so, the aim of this study was determining the normal value of urinary calcium to creatinine ratio in healthy adolescent’s child...

Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. Methods Cardiomyocytes were derived from hiPS cells that were generated from two healthy donors...

SYNOPSIS. Three yolk polypeptides (YPs) are major constituents of eggs. YPs are synthesized in the fat body and in ovary associated cells, secreted into the blood and sequestered into developing oocytes. YPs are translated as precursors which can be processed to lower molecular weight polypeptides by dog pancreatic microsomes, suggesting signal peptide removal. YP synthesis in both ovary and fa...

introduction emerging hypotheses suggest a causal role for prenatal androgen exposure in some cases of autism spectrum disorders (asd). the ratios of the lengths of the bones of the 2nd to the 4th digits (2d:4d) are purported to be markers for prenatal androgen exposure and to be established early in gestation. ratio of second and fourth digits (2d:4d)  is usually used as a proxy for prenatal t...

it is well-known that the behavior of soil-structure systems can be well described using a limited number of non-dimensional parameters. this is the outcome of researches based on the premise that the foundation is bonded to the ground. here, it is shown the concept can be extended to systems with foundation uplift. a set of non-dimensional parameters are introduced which controls the main feat...

Split gill lamellae (epithelium plus cuticle) of hyperregulating Chinese crabs acclimated to fresh water were mounted in a modified Ussing chamber. Active and electrogenic absorption of sodium and chloride were measured as positive amiloride-sensitive and negative Cl--dependent short-circuit currents (INa, ICl), respectively. Both currents were characterized before and after treatment of the ti...

The Slick (Kcnt2) sodium-activated potassium (KNa) channel is a rapidly gating and weakly voltage-dependent and sodium-dependent potassium channel with no clearly defined physiological function. Within the dorsal root ganglia (DRGs), we show Slick channels are exclusively expressed in small-sized and medium-sized calcitonin gene-related peptide (CGRP)-containing DRG neurons, and a pool of chann...