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B efore 1979, kinases were only thought to stick phosphates on two of the twenty amino acids: serine and threonine. But then Tony Hunter discovered that tyrosine could also be phosphorylated (1, 2), thereby uncovering an entirely new mechanism of protein regulation in cells. Since then, Hunter has worked on all sorts of protein phos-phorylation events and the kinases that deliver them. Indeed, ...

message was that those who use a KingArmstrongmethod should standardize it by the manual method of King and Wootton (1956). Although most clinical chemists in the United Kingdom still use either a manual or mechanized King-Armstrong method, little help was offered to the increasing numbers of clinical chemists using either ,B-glycerophosphate or pnitrophenol phosphate as substrate. The relative...

Much experimental work was done in connection with the experimental lilters at Guintly and at the Corporation filters. The conclusion is reached that "in some way or other sand filtration exercises a selective action on water bacteria, and that in general the lactose fermenters are much more completely eliminated than other kinds. In other words, and as compared to English results, the total co...

The Internet is widely regarded as primarily a content delivery system. Yet historically, connectivity has mattered much more than content. Even on the Internet, content is not as important as is often claimed, since it is email that is still the true “killer app.” The primacy of connectivity over content explains phenomena that have baffled wireless industry observers, such as the enthusiastic...