Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Recently we reported that the pyridinylimidazole class of p38 mitogen-activated protein (MAP) kinase inhibitors potently inhibited the facilitated transport of nucleosides and nucleoside analogs in K562 cells. These compounds competed with the binding of nitrobenzylthioinosine (NBMPR) to K562 cells, consistent with inhibition of the NBMPR-sensitive equilibrative transporter (ENT1). In this stud...

alzheimers disease (ad) is by far the most common cause of dementia. definite diagnosis of ad is based on pathological findings. nincds-adrda criteria, published more than 25 years ago, are commonly used for the clinical diagnosis of ad. however, considering serious shortcomings of these criteria, new criteria have been proposed. according to these new criteria, ad can be diagnosed in predement...

Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...

The bifunctional undecaprenol kinase/phosphatase (UdpK) is a small, prokaryotic, integral membrane kinase, homologous with Escherichia coli diacylglycerol kinase and expressed by the dgkA gene. In Gram-positive bacteria, UdpK involved in homeostasis of bacterial undecaprenoid pool, where it converts to undecaprenyl phosphate (C55P) also catalyses reverse process. C55P universal lipid carrier cr...

Abstract: Aim: LK (B-lymphocyte kinase) is a protein from the family SRC (Proto-oncogene tyrosine-protein kinase), an important cell signaling molecule that influences cellular response. The BLK kinase has been potential target for cancer therapy. As result, this could be initial step toward development of novel inhibitors to fight cancer. Materials and Methods: A homology model human tyrosine ...

Steady-state enzyme kinetics is a cornerstone technique of biochemistry and related sciences since it allows the characterization quantification behaviour. Enzyme widely used to investigate physiological role enzymes, determine effects mutations characterize inhibitors. Well-known examples inhibitors treat diseases include anti-infectives (e.g., penicillin, clavulanic acid HIV protease inhibito...

Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes patients seek efficient therapies to achieve sustained remissions. The complex nature greatly complicates patients’ responses appropriate treatments. Objectives: This review was conducted focus on Janus kinase (JAK) pathway, evaluate its role as ne...