OBJECTIVE To determine the incidence, risk factors and outcomes of acute kidney injury in children undergoing cardiac surgery for congenital heart disease. METHODS We enrolled 208 patients undergoing cardiac surgery for congenital heart disease during January 2012 to March 2013. Acute kidney injury was defined as per Acute Kidney Injury Network criteria. RESULTS Twenty patients had Acute ki...

SARS-Cov2 infection is a highly transmissible disease associated with serious pulmonary disease. Renal involvement frequent and poor prognosis; however, mechanisms of kidney injury are not well established. We present patient severe acute injury. Kidney biopsy findings revealed pattern tubular necrosis isometric vacuolization the proximal tubule. The interstitium glomeruli were normal. Electron...

Kidney injury and related diseases have become quite common in recent years, attracted more attention. Sulforaphane, a kind of isothiocyanate, is widely distributed cruciferous plants it antioxidant. Specifically, sulforaphane can reduce oxidative damage by preventing cells from freeradical damage, degeneration, acting as an anti-inflammation, etc. This study summarized the investigations effec...

Background and Objective: Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that has been used in many cancers; however, it can damage renal cells. Capparis spinosa is an important therapeutic plant in Persian medicine that encompasses high amounts of bioac...

OBJECTIVE To assess the diagnostic and prognostic efficacy of urine neutrophil gelatinase-associated lipocalin in patients admitted to an intensive care unit. METHODS Longitudinal, prospective cohort study conducted in a cardiology intensive care unit. The participants were divided into groups with and without acute kidney injury and were followed from admission to the intensive care unit unt...

Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is ‎also believed that oxidative stress has a pivotal role in APAP-induced renal injury. ‎Therefore, protective effects of different antioxidants have been examined in APAP-‎induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. T...

Background: the supplementation of natural antioxidants such plant flavonoids may counteract the deleterious actions of gamma-irradiation and iron overload. Material and Methods: the protective effect of naringin (NIN) against kidney injury induced by γ-irradiation (IRR) (6.5 Gy) and/or iron dextran (ID) (50 mg/kg. b. w) has been studied in rats given 80 mg/kg b.w of NIN for 14 days before, and...

Polycystic kidney disease is an inherited condition, characterized by the development of cysts in the kidney, as well as in other organs. Patients with polycystic kidney can suffer from the same causes of acute kidney injury as the general population. Nephritic syndrome is an uncommon cause of acute kidney injury in the general population and less common in patients with polycystic kidney disea...

Epidemiologic studies document strong associations between acute or chronic kidney injury and tumors. However, whether these are linked by causation, in which direction, is unclear. Accumulating data from basic clinical research now shed light on this issue prompt us to propose a new pathophysiological concept with immanent implications the management of patients disease As central paradigm, re...