Glutathione (GSH) fulfills several essential functions: Detoxification of free radicals and toxic oxygen radicals, thiol-disulfide exchange and storage and transfer of cysteine. GSH is present in all mammalian cells, but may be especially important for organs with intense exposure to exogenous toxins such as the liver, kidney, lung and intestine. Within the cell mitochondrial GSH is the main de...

Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) g...

objective(s): repaglinide (rg) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. it has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. the aim of the present study was to examine the protective...

The status of lipid peroxidation was investigated in rats fed M. Koenigii (curry leaf) and B. juncea (Mustard). Concentration of malondialdehyde showed a significant decrease, while hydroperoxides and conjugated dienes were significantly increased in liver and heart of both the experimental groups. SOD and catalase activity was found to be increased in liver and heart of both the spices adminis...

Meister, 1979~) . In kidney and probably at other sites of high pglutamyl transpeptidase concentration, intracellular glutathione is transported to the membrane-bound enzyme; the products of enzyme action (y-glutamyl amino acids, cysteinylglycine) are taken up by the cell. Tissues such as muscle and liver, which have low activities of transpeptidase, transport glutathione to the blood plasma. G...

The enzymatic oxidation of reduced glutathione through a cytochrome c-linked system by a cell-free preparation of mouse kidney has been reported previously (1). Neubeck and Smythe (2) have reported the use of guinea pig liver to hydrolyze glutathione enzymatically with the liberation of cysteine; this system has been reviewed recently by Smythe (3). In this contribution the relative rates of en...

Mercury (II) is a highly toxic metal which induced oxidative stress in the living organism. In the present study we examined the effect of S-Allyl cysteine (SAC) against the mercuric chloride (Hgcl2) intoxicated in albino rat model. The animals were treated with sub-leathal dose of mercuric chloride (1.23 mg/kg body wt) for 7 days. After scheduled treatetment the animals were decapitated and wh...