There is a growing emphasis on the relationship between the complexity and diversity of the microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease, including brain health and disorders of the central nervous system. The microbiota-gut-brain axis is a dynamic matrix of tissues and organs including the brain, glands, gut, immune cells and gastrointestinal micro...

Atherosclerotic plaque rupture and subsequent thrombosis is the main cause of sudden coronary death. Remarkably, atherosclerosis only develops in certain predisposed areas of the vasculature. Endothelial cells in these predisposed areas experience low or oscillatory shear stress, which activates the proinflammatory and procoagulant transcription factors activator protein 1 (AP-1) and nuclear fa...

The recent discovery of sphingolipid-derived second messengers that regulate fundamental cell responses such as cell growth and apoptosis has provided insight into the way cells sense and respond to stressful stimuli. This will help the understanding of the pathogenesis of stress-related diseases and eventually offer novel therapeutic approaches.

Replicative stress is a tumor cell-associated feature that includes the accumulation of stalled or collapsed replication forks. With the DNA polymerases lagging behind the helicases, these structures contain extended regions of single stranded DNA, leading to the activation of a damage signaling pathway that includes the kinases Ataxia Telangiectasia Mutated-Related (ATR) and Chk1. The specific...

Reactive oxygen species (ROS) play an integral role as signalling molecules in the regulation of numerous biological processes such as growth, development, and responses to biotic and/or abiotic stimuli in plants. To some extent, various functions of ROS signalling are attributed to differences in the regulatory mechanisms of respiratory burst oxidase homologues (RBOHs) that are involved in a m...

This study aimed at investigating the effect of visual (Cuisenaire Rods) and auditory nonsensical monosyllables using Pratt speech processing software as teaching techniques on retention of word stress. To this end, 60 high school participants made the two experimental groups of the study each having 30 students on the basis of their proficiency scores on KET (Key English Test). In one experime...